• Publications
  • Influence
The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
TLDR
It is proposed that SIRT1 functions as an enzymatic rheostat of circadian function, transducing signals originated by cellular metabolites to the circadian clock.
Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation.
TLDR
It is reported that histone acetylation and phosphorylation are synergistic, and this results illustrate how the addition of multiple histone modifications may be coupled during the process of gene expression.
Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1
TLDR
An interlocked transcriptional-enzymatic feedback loop that governs the molecular interplay between cellular metabolism and circadian rhythms in mouse embryo fibroblasts is revealed.
Circadian Regulator CLOCK Is a Histone Acetyltransferase
TLDR
Identification of CLOCK as a novel type of DNA binding HAT reveals that chromatin remodeling is crucial for the core clock mechanism and identifies unforeseen links between histone acetylation and cellular physiology.
ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology Implication for Coffin-Lowry Syndrome
TLDR
This work identifies the transcription factor ATF4 as a critical substrate of RSK2 that is required for the timely onset of osteoblast differentiation, for terminal differentiation of osteoblasts, and for osteoplast-specific gene expression and indicates that lack of ATF4 phosphorylation by R SK2 may contribute to the skeletal phenotype of CLS.
Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor
TLDR
It is reported that CREM is unique within the family of cAMP-responsive promoter element (CRE)-binding factors since it is inducible by activation of the cAMP signaling pathway and constituting a negative autoregulatory loop.
Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity
TLDR
The results reveal that signaling-dependent activation of mPer genes is distinct from the CLOCK/BMAL1-driven transcription required within the clock feedback loop, and constitute strong evidence that CREB acts as a pivotal endpoint of signaling pathways for the regulation of m per genes.
An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
TLDR
The gene responsible for the disease, DAX-1, which is deleted or mutated in X-linked adrenal hypoplasia patients, is isolated and encodes a new member of the nuclear hormone receptor super-family displaying a novel DNA-binding domain.
CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
TLDR
Using PCR and RNAase protection analysis, this gene, termed CREM, is isolated from a mouse pituitary cDNA library and three mRNA isoforms are identified that appear to be obtained by differential cell-specific splicing.
Signaling to Chromatin through Histone Modifications
TLDR
This review concludes with a recommendation that further studies are needed into the determinants of immune-inflammatory bowel disease and the Kessler-Corsi verdict is in order.
...
1
2
3
4
5
...