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A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates.
Cell therapy holds promise for tissue regeneration, including in individuals with advanced heart failure. However, treatment of heart disease with bone marrow cells and skeletal muscle progenitorsExpand
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Functional and molecular characterization of a T-type Ca(2+) channel during fetal and postnatal rat heart development.
T-type calcium current (I(CaT)) is distributed among a large variety of species and tissues. The main functions of I(CaT) are thought to be related to pacemaker activity and to the cell cycle. UsingExpand
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Targeting of c-kit+ haematopoietic progenitor cells prevents hypoxic pulmonary hypertension
Haematopoietic c-kit+ progenitor cells may contribute to pulmonary vascular remodelling and pulmonary hypertension (PH). Stromal derived factor-1 (SDF-1/CXCL12) and its receptors CXCR4 and CXCR7 haveExpand
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Pulse Pressure, Aortic Reactivity, and Endothelium Dysfunction in Old Hypertensive Rats
The reactivity of old hypertensive rat aortas has not been investigated in relation to each phenotype of the blood pressure curve, mean arterial pressure (MAP), and pulse pressure (PP). AorticExpand
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The nitrendipine-sensitive Ca2+ channel in chick muscle cells and its appearance during myogenesis in vitro and in vivo.
The nitrendipine-sensitive Ca2+ channel of chick skeletal myotubes in culture has been studied using both the 45Ca2+ flux technique and [3H]nitrendipine binding experiments. Ca2+ uptake isExpand
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Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats.
In rats, removal of the carotid arterial or abdominal aortic endothelium results in an acute increase of diameter and compliance. In humans, acute local administration of a specific NO synthaseExpand
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Chronic hemodynamic overload of the atria is an important factor for gap junction remodeling in human and rat hearts.
OBJECTIVES The expression and distribution of connexins is abnormal in a number of cardiac diseases, including atrial fibrillation, and is believed to favor conduction slowing and arrhythmia. Here,Expand
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Angiotensin II Signaling Pathways Mediate Expression of Cardiac T-Type Calcium Channels
Abstract— Recent studies indicate that cardiac T-type Ca2+ current (ICaT) reappears in hypertrophied ventricular cells. The aim of this study was to investigate the role of angiotensin II (Ang II), aExpand
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Comparative reactivity and mechanical properties of human isolated internal mammary and radial arteries.
OBJECTIVE The aim of this study was to analyse the arterial wall mechanics and the vasoreactive properties of the radial artery in comparison with those of the internal mammary artery and to discussExpand
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Excitation contraction coupling in skeletal muscle: evidence for a role of slow Ca2+ channels using Ca2+ channel activators and inhibitors in the dihydropyridine series.
Ca2+ current and tension have been simultaneously recorded from single twitch fibres of the semi-tendinosus of Rana esculenta in a medium containing a physiological Ca2+ concentration (1.8 mM). UnderExpand
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