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ADR-529

Known as: ADR 529, ADR529 
 
National Institutes of Health

Papers overview

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2004
2004
SummaryThe purpose of this study was to evaluate the optimal timing of ADR-529 administration to protect rats treated with… Expand
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Highly Cited
1996
Highly Cited
1996
Dexrazoxane [(DZR), ADR 529, ICRF-187] ameliorates doxorubicin (DOX)-induced cardiotoxicity in animals, and is recommended as a… Expand
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Review
1995
Review
1995
Chemotherapy drugs have been reported to cause cardiac side effects including cardiomyopathy, ischemia, arrhythmias, and… Expand
Highly Cited
1994
Highly Cited
1994
Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and… Expand
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Highly Cited
1993
Highly Cited
1993
The effect of the bisdioxopiperazine cardioprotector ICRF-187 (ADR-529, dexrazoxan) on drug-induced DNA damage and cytotoxicity… Expand
Highly Cited
1992
Highly Cited
1992
In this study doxorubicin, epirubicin, and mitoxantrone were compared for their cardiotoxic potential in a chronic mouse model in… Expand
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Highly Cited
1992
Highly Cited
1992
BACKGROUND Although doxorubicin is an anticancer agent with a wide spectrum of activity, therapy with this anthracycline must… Expand
1992
1992
ADR-529 protects against anthracycline cardiotoxicity, possibly by preventing free radical induction. We hypothesize that this… Expand
Review
1991
Review
1991
Anthracyclines are anticancer agents that are effective in a wide range of tumors. Unfortunately, their activity is limited by… Expand
1990
1990
Iron-catalyzed free radical reactions, such as the peroxidation of membrane lipids or the inactivation of critical enzymes, have… Expand