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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
- J. Chirgwin, A. Przybyla, Raymond J MacDonald, W. Rutter
- Chemistry, Biology
- 27 November 1979
Intact ribonucleic acid (RNA) has been prepared from tissues rich in ribonuclease such as the rat pancreas by efficient homogenization in a 4 M solution of the potent protein denaturant guanidinium… Expand
The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling
A cloned approximately 5 kb cDNA (human placenta) contains the coding sequences for the insulin receptor. The nucleotide sequence predicts a 1382 amino acid precursor. The alpha subunit comprises the… Expand
An ultrastructural analysis of the developing embryonic pancreas.
This ultrastructural analysis of pancreas development under in vivo and in vitro conditions complements earlier biochemical studies. The endocrine and exocrine tissue develops similarly in vitro. The… Expand
Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin
The formation of disulphide bonds is essential to the structure and function of proteins. These bonds rapidly form either co-translationally or immediately post-translationally in the lumen of the… Expand
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose
Insulin stimulates the autophosphorylation of tyrosine residues of the beta subunit of the insulin receptor (IR); this modified insulin-independent kinase has increased activity toward exogenous… Expand
Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development.
Trophoblast cells are the first lineage to form in the mammalian conceptus and mediate the process of implantation. We report the cloning of a basic helix-loop-helix (bHLH) transcription factor gene,… Expand
Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.
The distal portion of the rat insulin I gene 5'-flanking DNA contains two sequence elements, the Far and FLAT elements, that can function in combination, but not separately, as a beta-cell-specific… Expand
Synthesis and assembly of hepatitis B virus surface antigen particles in yeast
The surface antigen of hepatitis B virus (HBsAg) has been synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5′-flanking region of yeast alcohol… Expand
Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors.
- G. Gittes, P. Galante, D. Hanahan, W. Rutter, H. T. Debase
- Biology, Medicine
- 1 February 1996
Pancreatic organogenesis has been a classic example of epitheliomesenchymal interactions. The nature of this interaction, and the way in which endocrine, acinar and ductal cell lineages are generated… Expand