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senkirkine

Known as: 12-hydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Pyrrolizidine Alkaloids
neosenkirkine

Narrower (1)

senkirkine, (15E)-isomer

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine.
SCOPE 1,2-Unsaturated pyrrolizidine alkaloids (PA) are found in plants such as Asteraceae and Boraginaceae families. Acute PA… 
2012
2012
Comparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates
Toxicity of pyrrolizidine alkaloids (PAs) largely depends on their metabolic activation by hepatic enzymes, including cytochrome… 
2008
2008
Pyrrolizidine alkaloids of the endemic Mexican genus Pittocaulon and assignment of stereoisomeric 1,2-saturated necine bases.
2004
2004
On-line structure characterization of pyrrolizidine alkaloids in Onosma stellulatum and Emilia coccinea by liquid chromatography-ion-trap mass spectrometry.
2002
2002
Structure–Activity Relationships of Pyrrolizidine Alkaloids in Insect Chemical Defense Against the Orb-Weaving Spider Nephila clavipes
Pyrrolizidine alkaloids (PAs) are known to protect Arctiidae moths and Danainae and Ithomiinae butterflies against the orb… 
1996
1996
A competitive enzyme immunoassay for the pyrrolizidine alkaloids of the senecionine type.
We developed an immunoassay with antibodies against retrorsine to detect the closely related senecionine, the main alkaloid in… 
1988
1988
Macrocyclic pyrrolizidine alkaloids from Senecio anonymus. Separation of a complex alkaloid extract using droplet counter-current chromatography.
Ten 12-membered macrocyclic pyrrolizidine alkaloids, all of them esters of the necines, retronecine or otonecine, have been… 
1982
1982
Neosenkirkine and Senkirkine from Senecio pierotii
Two pyrrolizidine alkaloids, neosenkirkine and senkirkine were isolated from the roots and aerial parts of Senecio pierotii. As… 
1980
1980
Chromosomal aberrations and mutation in cultured mammalian cells induced by pyrrolizidine alkaloids.
1976
1976
The occurrence of senkirkine in Tussilago farfara
The medicinal herb, Tussilago farfara L., is shown to contain the hepatotoxic pyrrolizidine alkaloid, senkirkine. 
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