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Chemical ecology of pyrrolizidine alkaloids
- T. Hartmann
- 17 February 1999
In the following century, functional aspects of secondary metabolism were rejected or ignored by most plant scientists and those discussions of function that did appear were met with controversy (for details see Mothes 1955; Swain 1977; Haslam 1986; Luckner 1990).
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.
Anti-Ang2 therapy prevented VEGF-stimulated neovascularization in a rat corneal model of angiogenesis and implies that specific Ang2 inhibition may represent an effective antiangiogenic strategy for treating patients with solid tumors.
From waste products to ecochemicals: fifty years research of plant secondary metabolism.
- T. Hartmann
- Biology, MedicinePhytochemistry
- 1 November 2007
Chapter Four - Chemistry, Biology and Chemoecology of the Pyrrolizidine Alkaloids
Senecionine n-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris
Root cultures of Senecio vulgaris synthesize pyrrolizidine alkaloids which are accumulated in the form of their N -oxides, and Senecionine N -oxide is found to be the primary product of biosynthesis.
Diversity and variability of plant secondary metabolism: a mechanistic view
- T. Hartmann
- 1 July 1996
Facts and arguments are presented favouring the hypothesis that secondary metabolism evolved under the selection pressure of a competitive environment and the high ‘degree of chemical freedom’ of secondary metabolism is stressed as mechanistic basis for the generation of chemical diversity.
The cullin protein family
Genetic studies in several model organisms have helped to unravel a multitude of physiological functions associated with cullin proteins and their respective CRLs, which have an impact on a range of biological processes, including cell growth, development, signal transduction, transcriptional control, genomic integrity and tumor suppression.
The two facies of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insects with acquired plant alkaloids.
- R. Lindigkeit, A. Biller, M. Buch, H. Schiebel, M. Boppré, T. Hartmann
- Biology, MedicineEuropean journal of biochemistry
- 1 May 1997
The novel enzyme was named senecionine N-oxygenase (SNO), which isolated from the haemolymph of the sequestering arctiid Tyria jacobaeae and purified to electrophoretic homogeneity, and showed the same general substrate specificity but differ in their affinities towards the main structural types of pyrrolizidine alkaloids.
Chemical diversity and variation of pyrrolizidine alkaloids of the senecionine type: biological need or coincidence?
It is suggested that in constitutive plant defence, without significant turnover of its components, such a highly plastic system provides a powerful strategy to successfully defend and possibly escape herbivory.
Validation of a Self-Excising Marker in the Human Pathogen Aspergillus fumigatus by Employing the β-Rec/six Site-Specific Recombination System
- T. Hartmann, M. Dümig, +4 authors S. Krappmann
- Medicine, BiologyApplied and Environmental Microbiology
- 23 July 2010
ABSTRACT Recyclable markers based on site-specific recombination allow repetitive gene targeting in filamentous fungi. Here we describe for the first time functionality of the bacterial recombination…