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Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.
Kinetic analysis demonstrates that wortmannin is a noncompetitive, irreversible inhibitor of phosphatidylinositol-3-kinase, with inactivation being both time- and concentration-dependent. Expand
Thioredoxin reductase.
The importance of Trx to many aspects of cell function make it likely that TrxRs also play a role in protection against oxidant injury, cell growth and transformation, and the recycling of ascorbate from its oxidized form. Expand
Passing the baton: the HIF switch.
  • M. Koh, G. Powis
  • Biology, Medicine
  • Trends in biochemical sciences
  • 1 September 2012
The significance of the HIF switch and the relation between Hif-1 and HIF-2 under both physiological and pathophysiological conditions are reviewed. Expand
Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
The results show that the ether lipid analogues at cytotoxic concentrations are selective inhibitors of PIPLC and that the inhibition of PipLC may be related to the growth inhibitory activity of the ether cholesterol analogues. Expand
Properties and biological activities of thioredoxins.
  • G. Powis, W. Montfort
  • Chemistry, Medicine
  • Annual review of pharmacology and toxicology
  • 1 June 2001
The mammalian thioredoxins are a family of small redox proteins that undergo NADPH-dependent reduction by thiOREDoxin reductase and in turn reduce oxidized cysteine groups on proteins. Expand
Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.
Molecular modeling studies showed that different conformations imposed by mutant KRas may lead to altered association with downstream signaling transducers, and implies that therapeutic interventions may need to take into account the specific mutants expressed by the tumor. Expand
Redox Potential of Human Thioredoxin 1 and Identification of a Second Dithiol/Disulfide Motif*
Results suggest that the Cys-62-Cys-69 disulfide could provide a means to transiently inhibit Trx1 activity under conditions of redox signaling or oxidative stress, allowing more time for the sensing and transmission of oxidative signals. Expand
3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth.
This work represents the first attempt to examine the effects of 3-modified PI analogues on these two crucial cell signaling proteins, PI3-K and Akt, in an effort to better understand their cell growth inhibitory properties. Expand
HIF-1 regulation: not so easy come, easy go.
The hypoxia-inducible factor-1 (HIF-1) is the master regulator of the cellular response to hypoxia and its expression levels are tightly controlled through synthesis and degradation. It is widelyExpand
The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice
The results show that the mitochondrial redox protein Trx-2 is required for normal development of the mouse embryo and for actively respiring cells. Expand