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Pyrrolizidine Alkaloids

Known as: Alkaloids, Pyrrolizidine, Pyrrolizidine Alkaloids [Chemical/Ingredient], pyrrolizidine alkaloid 
A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE… 
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (44)

1-aminopyrrolizidine19-hydroxysenecionine4-hydroxy-nemorensic acidacetylnorloline

Broader (2)

AlkaloidsCarcinogens
In Bloodagonistsantagonists & inhibitorschemical synthesis

Papers overview

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Highly Cited
2004
Highly Cited
2004
Sites of synthesis, translocation and accumulation of pyrrolizidine alkaloid N-oxides in Senecio vulgaris L.
Abstract14C-Labelled alkaloid precursors (arginine, putrescine, spermidine) fed to Senecio vulgaris plants via the root system… 
Highly Cited
2003
Highly Cited
2003
Human liver microsomal metabolism and DNA adduct formation of the tumorigenic pyrrolizidine alkaloid, riddelliine.
Riddelliine, a widespread naturally occurring genotoxic pyrrolizidine alkaloid, induced liver tumors in rats and mice in an NTP 2… 
Highly Cited
2002
Highly Cited
2002
Diversity of pyrrolizidine alkaloids in Senecio species does not affect the specialist herbivore Tyria jacobaeae
Abstract. The evolution of the diversity of related secondary metabolites in plants is still poorly understood. It is often… 
Highly Cited
2000
Highly Cited
2000
Synthesis of polyhydroxylated pyrrolizidine alkaloids of the alexine family by tandem ring-closing metathesis-transannular cyclization. (+)-Australine.
Dienes 23 and 54, prepared from epoxy alcohol 9 via oxazolidinones 15 and 51, respectively, underwent ring-closing metathesis… 
Highly Cited
1999
Highly Cited
1999
Pyrrolizidine alkaloids crosslink DNA with actin.
Pyrrolizidine alkaloids (PAs) are toxic constituents of hundreds of plant species, some of which people are exposed to in herbal… 
Highly Cited
1995
Highly Cited
1995
Pyrrolizidine alkaloid-induced DNA-protein cross-links.
Pyrrolizidine alkaloids (PAs) are potent carcinogenic and anti-mitotic compounds produced by a large number of plant species. In… 
Highly Cited
1990
Highly Cited
1990
Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrrole.
Highly Cited
1977
Highly Cited
1977
Carcinogenic activity of petasitenine, a new pyrrolizidine alkaloid isolated from Petasites japonicus Maxim.
The carcinogenic activity of petasitenine, a new pyrrolizidine alkaloid isolated from young flower stalk of Petasites japonicus… 
Highly Cited
1974
Highly Cited
1974
Pyrrolizidine ester alkaloid in danaid butterflies
THE dihydropyrrolizines (I–III, Fig. 1a) found in the hairpencil secretions of male butterflies of the sub-family Danainae1–5 and… 
Highly Cited
1968
Highly Cited
1968
Tumor-inhibitory activity of pyrrolizidine alkaloids.
Eighteen pyrrolizidine alkaloids and several derivatives have been examined for tumor-inhibitory properties. Of these, 10… 
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