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Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms
This review presents updated information on the metabolism, metabolizing enzymes, and the mechanisms by which pyrrolizidine alkaloids exert genotoxicity and tumorigenicity.
Mechanisms of nanotoxicity: generation of reactive oxygen species.
Characterization, identification of ambient air and road dust polycyclic aromatic hydrocarbons in central Taiwan, Taichung.
Genotoxicity of pyrrolizidine alkaloids
Overall, PAs are mutagenic in vivo and in vitro and their mutagenicity appears to be responsible for the carcinogenesis of PAs.
Metabolism of phenanthrene by the white rot fungus Pleurotus ostreatus
- L. Bezalel, Y. Hadar, P. Fu, J. Freeman, C. Cerniglia
- Chemistry, BiologyApplied and environmental microbiology
- 1 July 1996
These experiments with cytochrome P-450 inhibitors and 18O2 labeling and the formation of phenanthrene trans-9R,10R-dihydrodiol as the predominant metabolite suggest that P. ostreatus initially oxidizesphenanthrene stereoselectively by a cyto chrome P- 450 monoxygenase and that this is followed by epoxide hydrolase-catalyzed hydration reactions.
Ginkgo Biloba Leave Extract: Biological, Medicinal, and Toxicological Effects
Ginkgo biloba leave extract is among the most widely sold herbal dietary supplements in the United States and has been prescribed to treat CNS disorders such as Alzheimer's disease and cognitive deficits.
Characterization of particulate, metallic elements of TSP, PM(2.5) and PM(2.5-10) aerosols at a farm sampling site in Taiwan, Taichung.
Photomutagenicity of 16 polycyclic aromatic hydrocarbons from the US EPA priority pollutant list.
Ambient suspended particulate matters and related chemical species study in central Taiwan, Taichung during 1998–2001
Genotoxic Pyrrolizidine Alkaloids — Mechanisms Leading to DNA Adduct Formation and Tumorigenicity
The results of recent mechanistic studies suggest that pyrrolizidine alkaloids induce tumors via a genotoxic mechanism mediated by 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5HpyrrolIZine (DHP)-derived DNA adduct formation.