P. Fu | Semantic Scholar

Publications
Influence

Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms

P. Fu, Q. Xia, G. Lin, M. Chou
Chemistry, Biology
Drug metabolism reviews
1 January 2004

This review presents updated information on the metabolism, metabolizing enzymes, and the mechanisms by which pyrrolizidine alkaloids exert genotoxicity and tumorigenicity.

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Mechanisms of nanotoxicity: generation of reactive oxygen species.

P. Fu, Q. Xia, H. Hwang, P. Ray, Hongtao Yu
Biology, Chemistry
Journal of food and drug analysis
1 March 2014

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Characterization, identification of ambient air and road dust polycyclic aromatic hydrocarbons in central Taiwan, Taichung.

G. Fang, Cheng-Nan Chang, Yuh-Shen Wu, P. Fu, I. Yang, Ming-Hsiang Chen
Environmental Science
The Science of the total environment
5 July 2004

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Genotoxicity of pyrrolizidine alkaloids

Tao Chen, N. Mei, P. Fu
Biology, Chemistry
Journal of applied toxicology : JAT
1 April 2010

Overall, PAs are mutagenic in vivo and in vitro and their mutagenicity appears to be responsible for the carcinogenesis of PAs.

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Metabolism of phenanthrene by the white rot fungus Pleurotus ostreatus

L. Bezalel, Y. Hadar, P. Fu, J. Freeman, C. Cerniglia
Chemistry, Biology
Applied and environmental microbiology
1 July 1996

These experiments with cytochrome P-450 inhibitors and 18O2 labeling and the formation of phenanthrene trans-9R,10R-dihydrodiol as the predominant metabolite suggest that P. ostreatus initially oxidizesphenanthrene stereoselectively by a cyto chrome P- 450 monoxygenase and that this is followed by epoxide hydrolase-catalyzed hydration reactions.

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Ginkgo Biloba Leave Extract: Biological, Medicinal, and Toxicological Effects

P. Chan, Q. Xia, P. Fu
Biology
Journal of environmental science and health. Part…
7 September 2007

Ginkgo biloba leave extract is among the most widely sold herbal dietary supplements in the United States and has been prescribed to treat CNS disorders such as Alzheimer's disease and cognitive deficits.

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Characterization of particulate, metallic elements of TSP, PM(2.5) and PM(2.5-10) aerosols at a farm sampling site in Taiwan, Taichung.

G. Fang, Cheng-Nan Chang, Ming-Hsiang Chen
Environmental Science
The Science of the total environment
1 June 2003

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Photomutagenicity of 16 polycyclic aromatic hydrocarbons from the US EPA priority pollutant list.

Jian Yan, Lei Wang, P. Fu, Hongtao Yu
Chemistry
Mutation research
10 January 2004

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Ambient suspended particulate matters and related chemical species study in central Taiwan, Taichung during 1998–2001

G. Fang, Cheng-Nan Chang, Shyh-Chyi Chang
Environmental Science
1 April 2002

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Genotoxic Pyrrolizidine Alkaloids — Mechanisms Leading to DNA Adduct Formation and Tumorigenicity

P. Fu, Q. Xia, G. Lin, M. Chou
Chemistry, Biology
30 September 2002

The results of recent mechanistic studies suggest that pyrrolizidine alkaloids induce tumors via a genotoxic mechanism mediated by 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5HpyrrolIZine (DHP)-derived DNA adduct formation.

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