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Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer.
TLDR
Findings indicate that genetic variants in COX-2 may play a role in mediating susceptibility to esophageal cancer.
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
TLDR
Estimation of caffeine 3-demethylation activity in humans may be useful in the characterization of arylamine N-oxidation phenotypes and in the assessment of whether or not the hepatic levels of cytochrome P-450PA, as affected by environmental or genetic factors, contribute to interindividual differences in susceptibility to arieslamine-induced cancers.
p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity.
TLDR
Genotype and haplotype frequency distributions were strongly dependent on ethnicity; variant allele frequencies were highest in African-Americans (29.1%) and lowest in Mexican-American (12.2%).
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
TLDR
Genetic variation in Phase II conjugating enzymes can influence the efficacy of tamoxifen therapy for breast cancer, according to a retrospective study of breast cancer patients.
Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans.
TLDR
Comparison of results from PCR-RFLP genotyping with caffeine metabolism phenotyping in 42 individuals suggested that an additional slow-acetylator allele was present in the sampled population, and a G > A base-change in codon 64 that caused a Arg > Glu amino acid substitution was found, termed the 'M4' allele, which apparently causes a slow- acetylation phenotype.
Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1.
TLDR
Results indicate that CYP2E1 may be a genetic susceptibility factor involved in the early events leading to the development of esophageal cancer.
Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.
TLDR
A metabolic phenotyping procedure that can be used to determine concomitantly the hepatic CYP1A2 and NAT2 phenotypes is described and it is confirmed the valid use of the urinary molar ratio of AFMU/1-methylxanthine, even in alkaline urines.
Distribution and concordance of N-acetyltransferase genotype and phenotype in an American population.
TLDR
A comparison with two previous reports revealed subtle differences in genotype and allele distribution but exhibited overall similarity with other Caucasian-American populations, and genotyping alone provided an efficient, accurate method of analysis for acetylator status.
Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression.
TLDR
Because the polymorphism in hGSTA1 correlates with hG STA1 and h GSTA2 expression in liver, and hGstA1-1 andhGSTa2-2 exhibit differential catalysis of the detoxification of carcinogen metabolites and chemotherapeutics,The polymorphism is expected to be of significance for individual risk of cancer or individual response to chemotherAPEutic agents.
Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk.
TLDR
The association of risk with at least one low-activity COMT(Met) allele was strongest among the heaviest premenopausal women and among the leanest post menopausal women, suggesting that COMT, mediated by body mass index, may be playing differential roles in human breast carcinogenesis, dependent upon menopausal status.
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