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Pharmacokinetics for the Pharmaceutical Scientist
Simple Linear Models More Complicated Linear Models Complicated Linear Models Linear Multicompartment Disposition Parameters from Extravascular Downslope C,T Data Noncompartmental and System Analysis
Interpretation of percent dissolved-time plots derived from in vitro testing of conventional tablets and capsules.
  • J. Wagner
  • Environmental Science
    Journal of pharmaceutical sciences
  • 1 October 1969
TLDR
The new method of dissolution rate data examination is capable of providing characterizing parameters of greater potential utility than conventional treatments heretofore used, and relationships between many of the constants in formerly derived dissolution rate equations and some equations derived in this report are shown.
Per cent absorbed time plots derived from blood level and/or urinary excretion data.
Here, dA/d t is the rate of absorption or the rate of appearance of the substance in the blood, V is the apparent volume of distribution, C is the blood level in concentration units at time t , dC/dt
Pharmacokinetics of ethanol after oral administration in the fasting state
TLDR
A preliminary model, based on physiological considerations, was elaborated and shown, for the first time, to describe the entire time course of blood alcohol concentrations after four different doses of alcohol.
Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics
  • J. Wagner
  • Chemistry
    Journal of Pharmacokinetics and Biopharmaceutics
  • 1 April 1973
TLDR
Some old equations are reviewed and some new equations have been derived which indicate certain properties of the Michaelis-Menten equation and its integrated forms which indicate the hybrid nature of ko.
A safe method for rapidly achieving plasma concentration plateaus
  • J. Wagner
  • Biology
    Clinical pharmacology and therapeutics
  • 1 October 1974
TLDR
A method is proposed in which initially a constant‐rate infusions at the rate of Q1 is given over T hours; then the rate is abruptly changed to a lower rate Q 2 which is maintained as long as steady state is desired.
History of pharmacokinetics.
  • J. Wagner
  • Biology
    Pharmacology & therapeutics
  • 1981
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