• Publications
  • Influence
Fundamentals of Clinical Pharmacokinetics
  • 1,199
  • 26
Pharmacokinetics for the Pharmaceutical Scientist
Simple Linear Models More Complicated Linear Models Complicated Linear Models Linear Multicompartment Disposition Parameters from Extravascular Downslope C,T Data Noncompartmental and System AnalysisExpand
  • 193
  • 17
Biopharmaceutics and Relevant Pharmacokinetics
  • 507
  • 14
Per cent absorbed time plots derived from blood level and/or urinary excretion data.
  • 360
  • 9
Interpretation of percent dissolved-time plots derived from in vitro testing of conventional tablets and capsules.
  • J. Wagner
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1 October 1969
It is shown that under sink conditions a percent dissolved value at time t may simply be equivalent to the percent surface area generated to time t. If this is so, then percent dissolved-time dataExpand
  • 463
  • 9
Pharmacokinetics of ethanol after oral administration in the fasting state
A nonlinear relationship between the total area under the blood ethanol concentration-time curve and the orally administered dose (mg/kg) of ethanol was observed in fasting subjects. A preliminaryExpand
  • 81
  • 8
Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man.
  • J. Wagner
  • Chemistry, Medicine
  • Journal of theoretical biology
  • 1 August 1968
Abstract An equation is proposed that may often be used to relate the intensity of a pharmacologic response to the concentration of drug in the body fluids of the intact animal or man. ConcentrationsExpand
  • 292
  • 6
A safe method for rapidly achieving plasma concentration plateaus
  • J. Wagner
  • Medicine
  • Clinical pharmacology and therapeutics
  • 1 October 1974
The classical procedure of administering a loading dose as a bolus intravenous iniection and at the same time starting an infusion at a constant rate could be dangerous or lead to toxicity withExpand
  • 177
  • 5
Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the
  • J. Wagner
  • Chemistry, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
  • 1 October 1976
It is shown that if the numerical values of the coefficients and exponents of the polyexponential equation describing the whole blood (plasma or serum) concentration after administration of a drug byExpand
  • 118
  • 5
Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics
  • J. Wagner
  • Chemistry, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
  • 1 April 1973
Some old equations are reviewed and some new equations have been derived which indicate certain properties of the Michaelis-Menten equation and its integrated forms. Simulated data which obeyExpand
  • 64
  • 5