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Multidrug Pump Inhibitors Uncover Remarkable Activity of Plant Antimicrobials
- G. Tegos, F. Stermitz, O. Lomovskaya, K. Lewis
- BiologyAntimicrobial Agents and Chemotherapy
- 1 October 2002
The results suggest that plants might have developed means of delivering their antimicrobials into bacterial cells and suggest that plant antimicroBials might be developed into effective, broad-spectrum antibiotics in combination with inhibitors of MDRs.
Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor.
- F. Stermitz, P. Lorenz, J. Tawara, L. Zenewicz, K. Lewis
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 15 February 2000
The level of accumulation of berberine in the cells was increased strongly in the presence of 5'-MHC, indicating that this plant compound effectively disabled the bacterial resistance mechanism against the berberines antimicrobial.
Enantiomeric-Dependent Phytotoxic and Antimicrobial Activity of (±)-Catechin. A Rhizosecreted Racemic Mixture from Spotted Knapweed1
It is found that (−)-catechin is a root-secreted phytotoxin that undoubtedly contributes to spotted knapweed's invasive behavior in the wild.
Biogeographical variation in community response to root allelochemistry: novel weapons and exotic invasion
Eurasian plants and soil microbes may have evolved natural resistance to 8-hydroxyquinoline while North American plants have not, suggesting a remarkable potential for evolutionary compatibility and homeostasis among plants within natural communities and a mechanism by which exotic weeds destroy these communities.
Molecular and Biochemical Characterization of an Enzyme Responsible for the Formation of Hypericin in St. John's Wort (Hypericum perforatum L.)*
- H. Bais, R. Vepachedu, C. Lawrence, F. Stermitz, J. Vivanco
- BiologyJournal of Biological Chemistry
- 22 August 2003
A direct and complex conversion of emodin to HyH that is solely catalyzed by Hyp-1, a Bet.v.1 class allergen from H. perforatum is demonstrated.
Acute Hepatitis Associated with the Chinese Herbal Product Jin Bu Huan
Seven adult patients (including the previously described patients) who ingested Jin Bu Huan are described and possible mechanisms for Jinbu Huan hepatotoxicity are discussed and serologic test results in all patients were negative for antinuclear, anti-smooth muscle, and antimitochondrial antibodies.
Host plant utilization and iridoid glycoside sequestration byEuphydryas anicia (Lepidoptera: Nymphalidae)
Large year-to-year and individual variation in butterfly iridoid content was established as was a female-male difference in macfadienoside vs. catalpol content.
Metabolic profiling of root exudates of Arabidopsis thaliana.
- T. S. Walker, H. Bais, K. Halligan, F. Stermitz, J. Vivanco
- Environmental ScienceJournal of agricultural and food chemistry
- 20 March 2003
An in vitro system implementing root-specific elicitation over a 48-day time course was developed and several compounds exhibited a wide range of antimicrobial activity against both soil-borne bacteria and fungi at the concentration detected in the root exudates.
Chemical Composition and Physical Characteristics of Unpopped Popcorn Hybrids
Abstract Kernel number, individual kernel weight, individual kernel volume, crude fat, crude protein, reducing sugars, starch content, amylose/amylopectin ratio and fatty acid composition were…
Iridoids. An updated review. Part I
Iridoid structures published for the first time during 1980-1989 are listed with available physical and spectral data: mp, [α]D, UV, 1 H nmr, 13 C nmr. Also included are revisions of iridoid…