• Publications
  • Influence
Carcinogenic activity of Symphytum officinale.
The carcinogenicity of Symphytum officinale L., Russian comfrey, used as a green vegetable or tonic, was studied in inbred ACI rats. Three groups of 19--28 rats each were fed comfrey leaves forExpand
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Metabolic fate of [14C] quercetin in the ACI rat.
To explain why quercetin, a mutagenic flavonoid distributed widely in edible plants, showed no carcinogenicity in experimental animals, overall metabolic fate of the drug was pursued usingExpand
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Induction of hepatic tumors in rats by senkirkine and symphytine.
The carcinogenicity of the pyrrolizidine alkaloids senkirkine and symphytine was studied in male inbred ACI rats. Animals were divided into 3 groups: Group I received ip injections of freshlyExpand
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Carcinogenic principles isolated from bracken fern.
  • I. Hirono
  • Biology, Medicine
  • Critical reviews in toxicology
  • 1986
The carcinogenicity of bracken fern, Pteridium aquilinum, was demonstrated most clearly by the experiment of Evans and Mason in 1965. We have performed fractionation of the aqueous extract by meansExpand
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Carcinogenicity examination of quercetin and rutin in ACI rats.
Carcinogenicity of quercetin and rutin were examined in inbred ACI strain rats. Rats were given a diet containing 1% or 5% quercetin or 5% rutin for 540 days, or 10% quercetin and 10% rutin for 850Expand
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Carcinogenicity test of quercetin and rutin in golden hamsters by oral administration.
Quercetin and its glycoside, rutin were tested for carcinogenicity in non-inbred golden hamsters of both sexes. In Experiment I, 10% quercetin, 10% rutin, or control diet was given to animals for 735Expand
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Test of carcinogenicity of quercetin, a widely distributed mutagen in food.
The carcinogenicity of quercetin, a flavonol, was tested in six-week-old ddY mice of both sexes. Groups of 38 males and 35 females were given pellet diet containing 2% quercetin throughout their lifeExpand
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Carcinogenic activity of processed bracken used as human food.
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K‐ras point mutations in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction
Pancreaticobiliary maljunction (PBM), an anomalous union of the pancreatic duct with the common bile duct, has frequently been shown to be associated with biliary carcinoma. However, the mechanism ofExpand
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Ptaquiloside, a novel norsesquiterpene glucoside from bracken, var.
An unstable norsesquiterpene glucoside with a novel illudane skeleton, ptaquiloside (1) has been isolated from bracken fern, Pteridium aquilinum var. latiusculum and the planar structure has beenExpand
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