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peginterferon alfa-2b

Known as: Pegylated Interferon Alpha-2b, Polyethylene Glycol IFN-A2b, PEG-IFN-a 2b 
A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The… Expand
National Institutes of Health

Papers overview

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Review
2013
Review
2013
The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Peginterferon plus ribavirin achieves sustained virological response (SVR) in fewer than half of patients with… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Treatment guidelines recommend the use of peginterferon alfa-2b or peginterferon alfa-2a in combination with ribavirin… Expand
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Highly Cited
2008
Highly Cited
2008
It is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In… Expand
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Highly Cited
2005
Highly Cited
2005
The incidence of hepatocellular carcinoma (HCC) has increased worldwide and is now the 5th most frequent cancer representing… Expand
Highly Cited
2004
Highly Cited
2004
BACKGROUND Treatment with pegylated interferon (peginterferon) and ribavirin for 48 weeks is more effective than conventional… Expand
Highly Cited
2001
Highly Cited
2001
BACKGROUND A sustained virological response (SVR) rate of 41% has been achieved with interferon alfa-2b plus ribavirin therapy of… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Only 15 to 20 percent of patients with chronic hepatitis C have a sustained virologic response to interferon therapy… Expand
Highly Cited
1994
Highly Cited
1994
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting… Expand
Highly Cited
1991
Highly Cited
1991
IL-10 inhibits the ability of macrophage but not B cell APC to stimulate cytokine synthesis by Th1 T cell clones. In this study… Expand