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Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation.
It is shown that PPARgamma mediates the proliferation and differentiation of murine NSCs via up-regulation of the epidermal growth factor receptor and activation of the ERK pathway, and regulates the development of the central nervous system during early embryogenesis via control of NSC proliferation. Expand
The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma.
The distribution of DNA junctions along the virus genome suggests that there are recombination-proficient regions, and all the integrated virus genomes were defective at least in one site around the cohesive end region, particularly within the X gene. Expand
Peroxisome Proliferator-activated Receptor γ-mediated Regulation of Neural Stem Cell Proliferation and Differentiation*
It is shown that PPARγ mediates the proliferation and differentiation of murine NSCs via up-regulation of the epidermal growth factor receptor and activation of the ERK pathway, and regulates the development of the central nervous system during early embryogenesis via control of NSC proliferation. Expand
Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application.
- H. Nabeshi, T. Yoshikawa, +21 authors Y. Tsutsumi
- Materials Science, Medicine
- 1 April 2011
The results suggested that the well-dispersed amorphous nanosilica of particle size 70 nm (nSP70) penetrated the skin barrier and caused systemic exposure in mouse, and induced mutagenic activity in vitro, indicated that further studies of relation between physicochemical properties and biological responses are needed for the development and the safer form of NMs. Expand
A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model.
The results suggest that gene delivery of PPAR gamma can be used to restore and/or enhance endogenous anti-inflammatory processes that are normally operative in mammalian tissues such as in the colon. Expand
Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins.
- T. Nakanishi, J. Kunisawa, +6 authors T. Mayumi
- Biology, Medicine
- Biochemical and biophysical research…
- 26 November 1997
Results indicate that the positive charge on the surface of liposomes represents an important factor for enhancing their immunoadjuvancy in the induction of antigen-specific immune responses. Expand
Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity.
The usefulness of the phage display system for creating functional mutant proteins and the development of a strategy for site-specific mono-PEGylation using tumor necrosis factor-alpha are suggested. Expand
Human tumor necrosis factor-alpha mutant RGD-V29 (F4614) shows potent antitumor activity and reduced toxicity against human tumor xenografted nude mice.
RGD-V29 appears to be a low-toxicity mutant of rhTNF that shows preferential activity towards tumors, and therefore merits further investigation in pre-clinical and clinical studies. Expand
PPAR gamma ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice.
- Tomoko Shiojiri, K. Wada, +7 authors Y. Kamisaki
- Biology, Medicine
- European journal of pharmacology
- 19 July 2002
Results indicate that PPARgamma ligands may possess anti-inflammatory activity against adjuvant-induced arthritis via the inhibition of NF-kappaB pathway. Expand
Efficient antigen gene transduction using Arg-Gly-Asp fiber-mutant adenovirus vectors can potentiate antitumor vaccine efficacy and maturation of murine dendritic cells.
Dendritic cells manipulation using the Arg-Gly-Asp fiber-mutant Ad system could advance the development of more effective vaccines and allow for more convenient administration of DC-based gene immunotherapy. Expand