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Block copolymer micelles for drug delivery: design, characterization and biological significance.
The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted. Expand
PEGylated Nanoparticles for Biological and Pharmaceutical Applications
The utility of polymeric micelles formed through the multimolecular assembly of block copolymer was comprehensively described as novel core-shell typed colloidal carriers for drug and gene targeting.Expand
Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance.
A remarkable improvement in blood circulation of DOX was achieved by use of PEG-PBLA micelle as a carrier presumably due to the reduced reticuloendothelial system uptake of the micelles through a steric stabilization mechanism. Expand
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size.
It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours. Expand
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
It is demonstrated that a delivery vehicle composed of gold nanoparticles conjugated to DNA and complexed with cationic endosomal disruptive polymers can deliver Cas9 ribonucleoprotein and donor DNA into a wide variety of cell types and efficiently correct the DNA mutation that causes Duchenne muscular dystrophy in mice via local injection, with minimal off-target DNA damage. Expand
Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and
In vitro and in vivo studies show that the micelles have the characteristic properties, such as an intracellular pH-triggered drug release capability, tumor-infiltrating permeability, and effective antitumor activity with extremely low toxicity. Expand
Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery.
Polymeric micelles are nanotechnology-based carrier systems that might exert the activity of potent bioactive compounds in a site-directed manner, ensuring their effectiveness and safety in the clinical use. Expand
Progress of drug-loaded polymeric micelles into clinical studies.
  • H. Cabral, K. Kataoka
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 28 September 2014
This review summarizes recent efforts in the development of self-assemblies of amphiphilic block copolymers consisting of a hydrophobic core as a drug reservoir and a poly(ethylene glycol) (PEG) hydrophilic shell as tumor-targeted nanocarriers with high translational potential and their performance in human studies. Expand
Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.
CDDP/m could be a promising formulation of CDDP for the targeted therapy of solid tumors, according to the passive targeting manner, and its utility as a tumor-targeted drug delivery system was investigated. Expand