Y. Nagasaki

Publications522
h-index62
Citations16,324
Highly Influential Citations177
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Block copolymer micelles for drug delivery: design, characterization and biological significance.
TLDR
The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted. Expand
PEGylated Nanoparticles for Biological and Pharmaceutical Applications
The utility of polymeric micelles formed through the multimolecular assembly of block copolymer was comprehensively described as novel core-shell typed colloidal carriers for drug and gene targeting.… Expand
PEGylated nanoparticles for biological and pharmaceutical applications.
TLDR
The potential utility of multimolecular assembly derived from heterobifunctional PEGs and block copolymers were explored to systematically modify the properties of metal and semiconductor nanostructures by controlling their structure and their surface properties, making them extremely attractive for use in biological and biomedical applications. Expand
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
TLDR
In vivo studies revealed that the PPD was potent in stabilizing MEND in the systemic circulation and facilitating tumor accumulation, and MEND modified with PPD is a promising device, which has the potential to make in vivo cancer gene therapy achievable. Expand
Quantitative and Reversible Lectin-Induced Association of Gold Nanoparticles Modified with α-Lactosyl-ω-mercapto-poly(ethylene glycol)
Gold nanoparticles (1−10 nm size range) were prepared with an appreciably narrow size distribution by in situ reduction of HAuCl4 in the presence of heterobifunctional poly(ethylene glycol) (PEG)… Expand
Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma…
The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling lactosylated-PEG-siRNA conjugates bearing acid-labile beta-thiopropionate linkages into polyion complex (PIC)… Expand
A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.
TLDR
Data demonstrate that introduction of both of a pH-sensitive fusogenic GALA peptide and PPD into the MEND facilitates nanoparticle endosomal escape, thereby enhancing the efficiency of siRNA delivery and gene silencing. Expand
Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid.
TLDR
This study reports on the systemic delivery of siRNA to tumors by employing a MEND that is modified with PPD (PPD-MEND), which revealed that PPD modification accelerated both cellular uptake and endosomal escape, compared to a conventional PEG modified MEND. Expand
Enhanced Growth Inhibition of Hepatic Multicellular Tumor Spheroids by Lactosylated Poly(ethylene glycol)‐siRNA Conjugate Formulated in PEGylated Polyplexes
TLDR
The data suggest that the smart PEGylated polyplexes can indeed penetrate into the multiple cell layers of 3D tumor masses in vivo, exerting therapeutic effects through the RNAi. Expand
Direct observation of adsorption-induced inactivation of antibody fragments surrounded by mixed-PEG layer on a gold surface.
TLDR
The results of the SPR analysis suggest that the adsorption-induced inactivation of the antigen-binding activity of Fab' took place gradually on the gold surface, where the activity disappeared almost completely at 60 min after Fab' immobilization. Expand
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