Block copolymer micelles for drug delivery: design, characterization and biological significance.
PEGylated Nanoparticles for Biological and Pharmaceutical Applications
PEGylated nanoparticles for biological and pharmaceutical applications.
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
In vivo studies revealed that the PPD was potent in stabilizing MEND in the systemic circulation and facilitating tumor accumulation, and MEND modified with PPD is a promising device, which has the potential to make in vivo cancer gene therapy achievable.
Quantitative and Reversible Lectin-Induced Association of Gold Nanoparticles Modified with α-Lactosyl-ω-mercapto-poly(ethylene glycol)
Lac-conjugated gold nanoparticles exhibited selective aggregation when exposed to Recinus communis agglutinin (RCA120), a bivalent lectin specifically recognizing the β-d-galactose residue, inducing significant changes in the absorption spectrum with concomitant visible color change from pinkish-red to purple.
Enhanced Growth Inhibition of Hepatic Multicellular Tumor Spheroids by Lactosylated Poly(ethylene glycol)‐siRNA Conjugate Formulated in PEGylated Polyplexes
The data suggest that the smart PEGylated polyplexes can indeed penetrate into the multiple cell layers of 3D tumor masses in vivo, exerting therapeutic effects through the RNAi.
Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid.
Direct observation of adsorption-induced inactivation of antibody fragments surrounded by mixed-PEG layer on a gold surface.
- Keitaro Yoshimoto, M. Nishio, Hiroaki Sugasawa, Y. Nagasaki
- Chemistry, BiologyJournal of the American Chemical Society
- 21 May 2010
The results of the SPR analysis suggest that the adsorption-induced inactivation of the antigen-binding activity of Fab' took place gradually on the gold surface, where the activity disappeared almost completely at 60 min after Fab' immobilization.
One-pot preparation of mono-dispersed and physiologically stabilized gold colloid
It was found that a hydroxylamine acted not only as a reducing agent, but also as a nucleation agent under alkaline reaction conditions, which may make the obtained colloidal dispersion suitable for biological applications.
Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma…
- M. Oishi, Y. Nagasaki, K. Itaka, N. Nishiyama, K. Kataoka
- Biology, ChemistryJournal of the American Chemical Society
- 22 January 2005
The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling lactosylated-PEG-siRNA conjugates bearing acid-labile beta-thiopropionate linkages into polyion complex (PIC)…