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Approximately 5% of patients with malignant gliomas have a family history of gliomas. Some of these familial cases are associated… Expand The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in… Expand BACKGROUND
Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has been shown to benefit patients with… Expand BACKGROUND
Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care… Expand The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with… Expand Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However… Expand Abstract For many years people have speculated that electroencephalographic activity or other electrophysiological measures of… Expand The most characteristic feature of microglial cells is their rapid activation in response to even minor pathological changes in… Expand The ability of p53 to activate transcription from specific sequences suggests that genes induced by p53 may mediate its… Expand Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer… Expand