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The Blood-Brain Barrier/Neurovascular Unit in Health and Disease
TLDR
Understanding how BBB TJ might be affected by various factors holds significant promise for the prevention and treatment of neurological diseases. Expand
Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier
TLDR
By allowing the "loosening" of TJs and an increase in paracellular permeability, the BBB is able to "bend without breaking"; thereby, maintaining structural integrity. Expand
Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation.
  • K. S. Mark, T. Davis
  • Biology, Medicine
  • American journal of physiology. Heart and…
  • 1 April 2002
TLDR
Results of this study show hypoxia-induced changes in paracellular permeability may be due to perturbation of TJ complexes and that posthypoxic reoxygenation reverses these effects. Expand
Oxidative Stress Increases Blood–Brain Barrier Permeability and Induces Alterations in Occludin during Hypoxia–Reoxygenation
TLDR
It is shown that oxidative stress produced during HR mediates an increase in BBB permeability in vivo using in situ brain perfusion and that pharmacological inhibition of disease states with an HR component may help preserve BBB functional integrity. Expand
Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression.
TLDR
It is shown that inflammatory-mediated pain alters both the functional and molecular properties of the BBB and may significantly alter delivery of therapeutic agents to the brain, thus affecting dosing regimens during chronic pain. Expand
Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations.
TLDR
During chronic inflammatory pain, alterations in BBB function are associated with changes in specific transmembrane TJ proteins, demonstrating that the blood-brain barrier can be modulated by disease pathologies including inflammatory pain. Expand
Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.
TLDR
Intraperitoneally administered L-serinyl beta-D-glucoside analogues of [Met5]enkephalin (glycopeptides) have been shown to be transported across the blood-brain barrier to bind with targeted mu- and delta-opioid receptors in the mouse brain. Expand
Vascular dysfunction—The disregarded partner of Alzheimer's disease
TLDR
Vascular imaging biomarkers of small vessel disease of the brain, which is responsible for >50% of dementia worldwide, including AD, are already established, well characterized, and easy to recognize and should be incorporated into the AD Research Framework to gain a better understanding of AD pathophysiology and aid in treatment efforts. Expand
Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke.
TLDR
Current knowledge in this area is summarized and pathways (i.e., oxidative stress, cytokine-mediated intracellular signaling, glial-expressed receptors/targets) that can be manipulated pharmacologically for preservation of BBB and glial integrity during ischemic stroke are emphasized. Expand
Transforming Growth Factor-β Signaling Alters Substrate Permeability and Tight Junction Protein Expression at the Blood-Brain Barrier during Inflammatory Pain
TLDR
Data show that TGF-β/ALK5 signaling is, in part, involved in the regulation of BBB functional integrity, as shown in rats subjected to CIP. Expand
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