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Interferon-alpha

Known as: IFN-A, alpha-interferon, Interferon.alpha 
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates… Expand
National Institutes of Health

Related topics

Related topics

46 relations

Narrower (23)

Alferon NDAI protocolIFNA13 protein, humanIFNA7 protein, human
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Antineoplastic AgentsIFNA1 geneIFNA17 geneIFNA2 gene
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Broader (2)

Immunologic FactorsInterferons

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma.
BACKGROUND Since sunitinib malate has shown activity in two uncontrolled studies in patients with metastatic renal-cell carcinoma… Expand
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Highly Cited
2006
Highly Cited
2006
5'-Triphosphate RNA Is the Ligand for RIG-I
The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm of virally infected cells is… Expand
Highly Cited
2005
Highly Cited
2005
Complete Replication of Hepatitis C Virus in Cell Culture
Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research… Expand
Highly Cited
2004
Highly Cited
2004
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
Double-stranded ribonucleic acid (dsRNA) serves as a danger signal associated with viral infection and leads to stimulation of… Expand
Review
2004
Review
2004
Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
  • D. Lavanchy
  • Journal of viral hepatitis
  • 2004
    • Corpus ID: 163757
Summary.  Hepatitis B virus (HBV) infection is a serious global health problem, with 2 billion people infected worldwide, and 350… Expand
Highly Cited
2003
Highly Cited
2003
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia.
BACKGROUND Imatinib, a selective inhibitor of the BCR-ABL tyrosine kinase, produces high response rates in patients with chronic… Expand
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Highly Cited
2001
Highly Cited
2001
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.
BACKGROUND BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine… Expand
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Highly Cited
1998
Highly Cited
1998
Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.
To better understand the dynamics of hepatitis C virus and the antiviral effect of interferon-alpha-2b (IFN), viral decline in 23… Expand
Review
1994
Review
1994
Cytokine therapeutics: lessons from interferon alpha.
  • J. Gutterman
  • Proceedings of the National Academy of Sciences…
  • 1994
    • Corpus ID: 2490970
Cytokines are soluble proteins that allow for communication between cells and the external environment. Interferon (IFN) alpha… Expand
Highly Cited
1986
Highly Cited
1986
Treatment of chronic non-A,non-B hepatitis with recombinant human alpha interferon. A preliminary report.
We treated 10 patients who had chronic non-A,non-B hepatitis with recombinant human alpha interferon in varying doses (0.5 to 5… Expand
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