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Interferon-alpha

Known as: IFN-A, alpha-interferon, Interferon.alpha 
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates… 
National Institutes of Health

Related topics

Related topics

46 relations

Narrower (23)

Alferon NDAI protocolIFNA13 protein, humanIFNA7 protein, human
Antineoplastic AgentsIFNA1 geneIFNA17 geneIFNA2 gene

Broader (2)

Immunologic FactorsInterferons

Papers overview

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Highly Cited
2006
Highly Cited
2006
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
Naive lymphocytes continually enter and exit lymphoid organs in a recirculation process that is essential for immune surveillance… 
Highly Cited
2004
Highly Cited
2004
The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression.
The mechanisms by which administration of interferon-alpha induces neuropsychiatric side effects, such as depressive symptoms and… 
Highly Cited
2003
Highly Cited
2003
Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy.
OBJECTIVE The authors assessed the relationship between the hypothalamic-pituitary-adrenal (HPA) axis response to interferon… 
Review
2001
Review
2001
Angiogenesis: regulators and clinical applications.
Highly Cited
2000
Highly Cited
2000
Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3.
Highly Cited
1993
Highly Cited
1993
Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.
Recently the cDNA encoding interleukin 13 (IL-13), a T-cell-derived cytokine, was cloned and expressed. The present study… 
Highly Cited
1991
Highly Cited
1991
Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy.
BACKGROUND Cirrhosis is a diffuse process of hepatic fibrosis and regenerative nodule formation of unknown pathogenesis… 
Highly Cited
1990
Highly Cited
1990
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.
A cytokine that can synergize with interleukin 2 to activate cytotoxic lymphocytes was purified to homogeneity. The protein… 
Highly Cited
1989
Highly Cited
1989
Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.
The signal transduction pathway through which interferon-alpha (IFN alpha) stimulates transcription of a defined set of genes… 
Highly Cited
1988
Highly Cited
1988
IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.
The effect of human recombinant interleukin 4 (IL-4) on antibody production by normal peripheral blood mononuclear cells enriched… 
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