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Since sunitinib malate has shown activity in two uncontrolled studies in patients with metastatic renal-cell carcinoma… Expand The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm of virally infected cells is… Expand Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research… Expand Double-stranded ribonucleic acid (dsRNA) serves as a danger signal associated with viral infection and leads to stimulation of… Expand Summary. Hepatitis B virus (HBV) infection is a serious global health problem, with 2 billion people infected worldwide, and 350… Expand BACKGROUND
Imatinib, a selective inhibitor of the BCR-ABL tyrosine kinase, produces high response rates in patients with chronic… Expand BACKGROUND
BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine… Expand To better understand the dynamics of hepatitis C virus and the antiviral effect of interferon-alpha-2b (IFN), viral decline in 23… Expand Cytokines are soluble proteins that allow for communication between cells and the external environment. Interferon (IFN) alpha… Expand We treated 10 patients who had chronic non-A,non-B hepatitis with recombinant human alpha interferon in varying doses (0.5 to 5… Expand