Interleukin-1 polymorphisms associated with increased risk of gastric cancer
It is reported that interleukin-1 gene cluster polymorphisms suspected of enhancing production of interleucine-1-beta are associated with an increased risk of both hypochlorhydria induced by H. pylori and gastric cancer.
Timing of the Last Glacial Maximum from observed sea-level minima
Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression.
Treatment of immunodeficient mice bearing human breast carcinoma cells with a neutralizing antibody to MCP-1 resulted in significant increases in survival and inhibition of the growth of lung micrometastases, indicating that M CP-1 can act as a direct mediator of angiogenesis.
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers
The ability of NKSF to directly induce IFN-gamma production and to synergize with other physiological IFN -gamma inducers, joined with the previously described ability to enhance lymphocyte cytotoxicity and proliferation, indicates that this lymphokine is a powerful immunopotentiating agent.
Interleukin 2 plays a central role in Th2 differentiation.
- J. Cote-Sierra, G. Foucras, W. Paul
- BiologyProceedings of the National Academy of Sciences…
- 16 March 2004
IL-2 plays a critical role in the polarization of naive CD4 T cells to the Th2 phenotype through restriction enzyme accessibility and binding of Stat5 to chromatin, indicating that IL-2 mediates its effect by stabilizing the accessibility of the Il4 gene.
Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation
- P. Hwu, M. X. Du, R. Lapointe, M. Do, Milton W. Taylor, H. Young
- Biology, ChemistryJournal of Immunology
- 1 April 2000
Results suggest that activation of DCs induces the production of functional IDO, which causes depletion of tryptophan and subsequent inhibition of T cell proliferation, which may represent a potential mechanism for DCs to regulate the immune response.
Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization.
- A. Mazzoni, H. Young, J. H. Spitzer, A. Visintin, D. Segal
- BiologyJournal of Clinical Investigation
- 15 December 2001
It is proposed that the Th2 cells favor IgE production, leading to increased histamine secretion by mast cells, thus creating a positive feedback loop that could contribute to the severity of atopic diseases.
Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells.
Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN
Ku70 mediates type III IFN induction by DNA for the first time, and is identified as a novel DNA sensor inducing the IFN-lambda1 activation.