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lacosamide

Known as: N-benzyl-AcMeOPrNH2, N-benzyl-2-acetamido-3-methoxypropionamide, Erlosamide 
A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with… 
National Institutes of Health

Related topics

Related topics

11 relations
20 ML lacosamide 10 MG/ML Injection [Vimpat]Antiepileptic AgentsEpilepsyHarkoseride

Broader (2)

AcetamidesAnticonvulsants

Narrower (1)

Vimpat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Anaesthesia and epilepsy.
Epilepsy is the most common serious neurological disorder, with a prevalence of 0.5-1% of the population. While the traditional… 
Review
2011
Review
2011
Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: A systematic review and meta‐analysis
Purpose:  Evaluate the clinical comparability of new antiepileptic drugs (AEDs) in partial refractory epilepsy. 
Review
2011
Review
2011
Pharmacotherapy of Epilepsy
This article discusses seven newly available antiepileptic drugs (AEDs) and agents in phase III development.Lacosamide, licensed… 
Highly Cited
2011
Highly Cited
2011
Intravenous lacosamide for treatment of status epilepticus
Kellinghaus C, Berning S, Immisch I, Larch J, Rosenow F, Rossetti AO, Tilz C, Trinka E. Intravenous lacosamide for treatment of… 
Highly Cited
2010
Highly Cited
2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase…
Coumarins constitute a general and totally new class of inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1… 
Review
2009
Review
2009
Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX)
Highly Cited
2009
Highly Cited
2009
2008 FDA drug approvals
Specialty products continued to dominate new drug and biologic approvals in the US in a year in which the evolving regulatory… 
Review
2009
Review
2009
Lacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partial-onset seizures
Lacosamide is an antiepileptic drug approved in the USA and Europe as adjunctive therapy for partial-onset seizures. Studies… 
Highly Cited
2008
Highly Cited
2008
Intravenous lacosamide as replacement for oral lacosamide in patients with partial‐onset seizures
Purpose: This multicenter, double‐blind, double‐dummy, randomized, inpatient trial evaluated the safety, tolerability, and… 
Review
2006
Review
2006
Diverse mechanisms of antiepileptic drugs in the development pipeline
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