• Publications
  • Influence
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
  • C. Supuran
  • Biology, Medicine
  • Nature Reviews Drug Discovery
  • 1 February 2008
The biological rationale for the novel uses of inhibitors or activators of CA activity in multiple diseases is discussed, and progress in the development of specific modulators of the relevant CA isoforms is highlighted, some of which are now being evaluated in clinical trials. Expand
Carbonic anhydrase inhibitors.
The use of such enzyme inhibitors as antiglaucoma drugs will be discussed in detail, together with the recent developments that led to isozyme-specific and organ-selective inhibitors. Expand
Carbonic anhydrases--an overview.
  • C. Supuran
  • Medicine
  • Current pharmaceutical design
  • 2008
Several important physiological and physio-pathological functions are played by CA isozymes present in organisms all over the phylogenetic tree, related to respiration and transport of CO(2)/bicarbonate between metabolizing tissues and the lungs, pH andCO(2) homeostasis, electrolyte secretion in a variety of tissues/organs, biosynthetic reactions, etc. Expand
Carbonic Anhydrase in the Scleractinian Coral Stylophora pistillata
STPCA is a secreted form of α-CA, which possesses a CA catalytic function, similar to the secreted human CAVI, and its localization at the calicoblastic ectoderm level supports the role of STPCA in the calcification process. Expand
Interfering with pH regulation in tumours as a therapeutic strategy
Key pH regulators in tumour cells include: isoforms 2, 9 and 12 of carbonic anhydrase, isoforms of anion exchangers, Na+/HCO3− co-transporters, Na+./H+ exchanger, monocarboxylate transporters and the vacuolar ATPase. Expand
Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH
It is shown that hypoxia regulates both expression and activity of CA IX in order to enhance the extracellular acidification, which may have important implications for tumor progression. Expand
Carbonic anhydrases in anthozoan corals-A review.
The current understanding of diversity and function of carbonic anhydrases in corals is reviewed and the perspective of theses enzymes as a key to understanding impacts of environmental changes on coral reefs is discussed. Expand
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
On the basis of the structural differences observed between CA IX and the other membrane-associated α-CAs, further prospects for the rational drug design of isozyme-specific CA inhibitors are proposed, given that inhibition of this enzyme shows antitumor activity both in vitro and in vivo. Expand
Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family*
The predicted amino acid sequence, structural model, distribution, and activity data suggest that CA XIII represents a novel enzyme, which may play important physiological roles in several organs. Expand
A New Coral Carbonic Anhydrase in Stylophora pistillata
Owing to its intracellular localisation in the oral endoderm and in the aboral tissue, it is proposed that STPCA-2 is involved in pH regulation and/or inorganic carbon delivery to symbiont and calcification. Expand