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Carbonic anhydrase inhibitors.
At least 14 different carbonic anhydrase (CA, EC isoforms were isolated in higher vertebrates, where these zinc enzymes play crucial physiological roles. Some of these isozymes are cytosolicExpand
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Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
Carbonic anhydrase (CA) IX is a plasma membrane-associated member of the α-CA enzyme family, which is involved in solid tumor acidification. It is a marker of tumor hypoxia and a prognostic factor inExpand
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Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family*
The carbonic anhydrase (CA) gene family has been reported to consist of at least 11 enzymatically active members and a few inactive homologous proteins. Recent analyses of human and mouse databasesExpand
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Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH
Acidic extracellular pH (pHe) is a typical attribute of a tumor microenviroment, which has an impact on cancer development and treatment outcome. It was believed to result from an accumulation ofExpand
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Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.
By optimizing binding to a selected target protein, modern drug research strives to develop safe and efficacious agents for the treatment of disease. Selective drug action is intended to minimizeExpand
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Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes*
Carbonic anhydrase IX (CA IX) is an exceptional member of the CA protein family; in addition to its classical role in pH regulation, it has also been proposed to participate in cell proliferation,Expand
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Carbonic Anhydrase: Its Inhibitors and Activators
Carbonic Anhydrases: Catalytic and Inhibition Mechanisms, Distribution and Physiological RolesC.T. SupuranAcatalytic CAs: Carbonic Anhydrase-Related ProteinsI. NishimoriMultiple Binding ModesExpand
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Bacterial protease inhibitors
Serine‐, cysteine‐, and metalloproteases are widely spread in many pathogenic bacteria, where they play critical functions related to colonization and evasion of host immune defenses, acquisition ofExpand
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Crystal structure of a blue laccase from Lentinus tigrinus: evidences for intermediates in the molecular oxygen reductive splitting by multicopper oxidases
BackgroundLaccases belong to multicopper oxidases, a widespread class of enzymes implicated in many oxidative functions in pathogenesis, immunogenesis and morphogenesis of organisms and in theExpand
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Carbonic anhydrases as targets for medicinal chemistry.
Carbonic anhydrases (CAs, EC are zinc enzymes acting as efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate. 16 different alpha-CA isoforms were isolated inExpand
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