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The neurobiology of antiepileptic drugs
The subtle biophysical modifications in channel behaviour that are induced by AEDs are often functionally opposite to defects in channel properties that are caused by mutations associated with epilepsy in humans. Expand
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
D-serine is an endogenous modulator of the glycine site of NMDA receptors and fully occupies this site at some functional synapses and greatly attenuates NMDA receptor-mediated neurotransmission as assessed by using whole-cell patch-clamp recordings or indirectly by using biochemical assays of the sequelae of NMda receptor- mediated calcium flux. Expand
Glia and epilepsy: excitability and inflammation
This review critically evaluates the role of glia-induced hyperexcitability and inflammation in epilepsy and points to a significant contribution by non-neuronal cells, the glia--especially astrocytes and microglia--in the pathophysiology of epilepsy. Expand
Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons.
It is concluded that the gating of the GABAA receptor channel by PHB and PB is functionally similar to that produced by the natural agonist GABA alone, but distinct from that obtained when barbiturates modulate the response to GABA. Expand
Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.
Antiepileptic drug pheny toin potentiates GABA in the rat cuneate nucleus and its metabolite as potent inhibitors of microsomal metabolism of phenytoin and carbamazepine. Expand
The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions
Emerging evidence suggests that effects on signaling pathways that regulate neuronal plasticity and survival may be a factor in the delayed clinical efficacy of AEDs in some neuropsychiatric conditions, including bipolar affective disorder. Expand
Diverse mechanisms of antiepileptic drugs in the development pipeline
  • M. Rogawski
  • Medicine, Chemistry
  • Epilepsy Research
  • 1 June 2006
There is a remarkable array of new chemical entities in the current antiepileptic drug (AED) development pipeline, and some pipeline compounds are believed to act through conventional targets, whereas others are structurally novel and may act by novel mechanisms. Expand
Molecular targets for antiepileptic drug development
SummaryThis review considers how recent advances in the physiology of ion channels and other potential molecular targets, in conjunction with new information on the genetics of idiopathic epilepsies,Expand
Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABAA Receptor Function and Seizure Susceptibility
Evidence is provided that GABAA receptor-modulating neurosteroids derived from deoxycorticosterone play a role in stress-related changes in seizure control and that DOC is a mediator of the physiological effects of acute stress that could contribute to stress-inducedChanges in seizure susceptibility. Expand
Revisiting AMPA Receptors as an Antiepileptic Drug Target
Promising clinical studies with AMPA receptor antagonists, including the potent noncompetitive antagonist perampanel, are once again focusing attention on AMPA receptors as a drug target for epilepsy therapy. Expand