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esperamicin A1

Known as: esperamicin 
An enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety. Esperamicin A1 is isolated from the bacterium Actinomadura… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Alkylating AgentsAminoglycosidesAntibiotics, AntineoplasticEnediynes

Narrower (1)

BMY 28175

Papers overview

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Highly Cited
2014
Highly Cited
2014
Abasic and oxidized abasic site reactivity in DNA: enzyme inhibition, cross-linking, and nucleosome catalyzed reactions.
Abasic lesions are a family of DNA modifications that lack Watson-Crick bases. The parent member of this family, the apurinic… 
2010
2010
Conformationally gated fragmentations and rearrangements promoted by interception of the Bergman cyclization through intramolecular H-abstraction: a possible mechanism of auto-resistance to natural…
A variety of fragmentations and rearrangements can follow Bergman cyclization in enediynes equipped with acetal rings mimicking… 
2005
2005
Theoretical simulation of the electronic circular dichroism spectrum of calicheamicin.
Highly Cited
2003
Highly Cited
2003
Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model
A universal PCR method for the rapid amplification of minimal enediyne polyketide synthase (PKS) genes and the application of… 
Highly Cited
1994
Highly Cited
1994
C1027 chromophore, a potent new enediyne antitumor antibiotic, induces sequence-specific double-strand DNA cleavage.
C1027, a new macromolecular antitumor antibiotic produced by a Streptomyces strain, shows highly potent cytotoxicity to cultured… 
1994
1994
Enediyne-mediated DNA damage in nuclei is modulated at the level of the nucleosome.
Highly Cited
1990
Highly Cited
1990
DNA intercalation and cleavage of an antitumor antibiotic dynemicin that contains anthracycline and enediyne cores.
Dynemicin is a hybrid containing anthraquinone and enediyne cores, which contribute to binding and cleavage of DNA, respectively… 
1989
1989
Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics.
The cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds. Oxygen and active oxygen-radical… 
1989
1989
Light-induced DNA cleavage by esperamicin and neocarzinostatin.
Highly Cited
1988
Highly Cited
1988
Synthesis of the bicyclic core of the esperamicin/calichemicin class of antitumor agents
triisopropylsilyl group, the extent of stereocontrol was increased to 97.4:2.6. In all cases, effect of the ester group overrode… 
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