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Abasic lesions are a family of DNA modifications that lack Watson-Crick bases. The parent member of this family, the apurinic… Expand The aglycon, or so-called 'warhead' portion, of several potent 10-membered ring enediyne antitumor antibiotics contain… Expand A universal PCR method for the rapid amplification of minimal enediyne polyketide synthase (PKS) genes and the application of… Expand A density functional theoretical study is presented, which implicates a novel S(3)-cleavage in the decomposition of a… Expand Although extensive effort has been applied toward understanding the mechanism by which enediynes cleave DNA, a continuous assay… Expand C1027, a new macromolecular antitumor antibiotic produced by a Streptomyces strain, shows highly potent cytotoxicity to cultured… Expand Dynemicin is a hybrid containing anthraquinone and enediyne cores, which contribute to binding and cleavage of DNA, respectively… Expand The esperamicins represent a class of antitumor antibiotics characterized by an unusual chemical core structure and extremely… Expand The cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds. Oxygen and active oxygen-radical… Expand triisopropylsilyl group, the extent of stereocontrol was increased to 97.4:2.6. In all cases, effect of the ester group overrode… Expand