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esperamicin A1

Known as: esperamicin 
An enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety. Esperamicin A1 is isolated from the bacterium Actinomadura… Expand
National Institutes of Health

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2014
2014
Abasic lesions are a family of DNA modifications that lack Watson-Crick bases. The parent member of this family, the apurinic… Expand
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2005
2005
SummaryAddition of cerulenin (0.25–1.0 mM) to cultures ofActinomadura verrucosospora before the onset of esperamicin synthesis… Expand
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2005
2005
The aglycon, or so-called 'warhead' portion, of several potent 10-membered ring enediyne antitumor antibiotics contain… Expand
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2003
2003
A universal PCR method for the rapid amplification of minimal enediyne polyketide synthase (PKS) genes and the application of… Expand
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2000
2000
Although extensive effort has been applied toward understanding the mechanism by which enediynes cleave DNA, a continuous assay… Expand
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1996
1996
The enediyne anti-tumour antibiotics are extremely potent cytotoxins, apparently because of their conversion to diradical species… Expand
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1995
1995
RNA cleavage by enediyne anticancer antibiotics was shown to occur with no apparent sequence selectivity, but RNA structure… Expand
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1994
1994
C1027, a new macromolecular antitumor antibiotic produced by a Streptomyces strain, shows highly potent cytotoxicity to cultured… Expand
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1989
1989
The esperamicins represent a class of antitumor antibiotics characterized by an unusual chemical core structure and extremely… Expand
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1989
1989
The cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds. Oxygen and active oxygen-radical… Expand
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