esperamicin A1

Known as: esperamicin 
An enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety. Esperamicin A1 is isolated from the bacterium Actinomadura… (More)

Topic mentions per year

Topic mentions per year

1988-2014
02419882014

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2014
2014
Abasic lesions are a family of DNA modifications that lack Watson-Crick bases. The parent member of this family, the apurinic… (More)
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2014
2014
Enediyne natural products are important member of natural product family with strong DNA cleavage activity. This biological… (More)
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2003
2003
A universal PCR method for the rapid amplification of minimal enediyne polyketide synthase (PKS) genes and the application of… (More)
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2000
2000
Although extensive effort has been applied toward understanding the mechanism by which enediynes cleave DNA, a continuous assay… (More)
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1997
1997
Esperamicin A1 is an enediyne antibiotic possessing antitumor activity associated with its ability to bind and, following… (More)
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1997
1997
Methylation of the C5 position of cytosine in CG dinucleotides represents an important element in the control of gene expression… (More)
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1996
1996
The enediyne anti-tumour antibiotics are extremely potent cytotoxins, apparently because of their conversion to diradical species… (More)
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1994
1994
C1027, a new macromolecular antitumor antibiotic produced by a Streptomyces strain, shows highly potent cytotoxicity to cultured… (More)
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1993
1993
Addition of cerulenin (0.25–1.0 mM) to cultures ofActinomadura verrucosospora before the onset of esperamicin synthesis inhibited… (More)
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1989
1989
The esperamicins represent a class of antitumor antibiotics characterized by an unusual chemical core structure and extremely… (More)
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