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esperamicin A1

Known as: esperamicin 
An enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety. Esperamicin A1 is isolated from the bacterium Actinomadura… Expand
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
Abasic lesions are a family of DNA modifications that lack Watson-Crick bases. The parent member of this family, the apurinic… Expand
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2005
2005
The aglycon, or so-called 'warhead' portion, of several potent 10-membered ring enediyne antitumor antibiotics contain… Expand
Highly Cited
2003
Highly Cited
2003
A universal PCR method for the rapid amplification of minimal enediyne polyketide synthase (PKS) genes and the application of… Expand
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2001
2001
  • A. Greer
  • Journal of the American Chemical Society
  • 2001
  • Corpus ID: 23849000
A density functional theoretical study is presented, which implicates a novel S(3)-cleavage in the decomposition of a… Expand
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Highly Cited
2000
Highly Cited
2000
Although extensive effort has been applied toward understanding the mechanism by which enediynes cleave DNA, a continuous assay… Expand
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Highly Cited
1994
Highly Cited
1994
C1027, a new macromolecular antitumor antibiotic produced by a Streptomyces strain, shows highly potent cytotoxicity to cultured… Expand
Highly Cited
1990
Highly Cited
1990
Dynemicin is a hybrid containing anthraquinone and enediyne cores, which contribute to binding and cleavage of DNA, respectively… Expand
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Highly Cited
1989
Highly Cited
1989
The esperamicins represent a class of antitumor antibiotics characterized by an unusual chemical core structure and extremely… Expand
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1989
1989
The cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds. Oxygen and active oxygen-radical… Expand
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Highly Cited
1988
Highly Cited
1988
triisopropylsilyl group, the extent of stereocontrol was increased to 97.4:2.6. In all cases, effect of the ester group overrode… Expand