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A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
Regulation of Ferroptotic Cancer Cell Death by GPX4
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
It is demonstrated that M2 expression is necessary for aerobic glycolysis and that this metabolic phenotype provides a selective growth advantage for tumour cells in vivo.
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Active genes are tri-methylated at K4 of histone H3
It is shown that the Saccharomyces cerevisiae Set1 protein can catalyse di- and tri-methylation of K4 and stimulate the activity of many genes, establishing the concept of methyl status as a determinant for gene activity and extending considerably the complexity of histone modifications.
Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse
A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p
A role for histone deacetylase as a key regulator of eukaryotic transcription is supported by the predicted protein, which is very similar to the yeast transcriptional regulator Rpd3p.
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
- S. Haggarty, K. M. Koeller, J. Wong, C. Grozinger, S. Schreiber
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 3 April 2003
It is suggested that small molecules that selectively inhibit HDAC6-mediated α-tubulin deacetylation, a first example of which is tubacin, might have therapeutic applications as antimetastatic and antiangiogenic agents.