• Publications
  • Influence
Repair of Formamidopyrimidines in DNA Involves Different Glycosylases
The oxidatively induced DNA lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA) are formed abundantly in DNA of cultured cells or tissues exposedExpand
  • 159
  • 7
Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells
Fapy·dG and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) are formed in DNA by hydroxyl radical damage. In order to study replication past these lesions in cells, we constructed a single-strandedExpand
  • 95
  • 6
  • Open Access
Replication termination mechanism as revealed by Tus-mediated polar arrest of a sliding helicase
The replication terminator protein Tus of Escherichia coli promotes polar fork arrest at sequence-specific replication termini (Ter) by antagonizing DNA unwinding by the replicative helicase DnaB.Expand
  • 38
  • 4
  • Open Access
Covalent Trapping of Human DNA Polymerase β by the Oxidative DNA Lesion 2-Deoxyribonolactone*
Oxidized abasic residues in DNA constitute a major class of radiation and oxidative damage. Free radical attack on the nucleotidyl C-1′ carbon yields 2-deoxyribonolactone (dL) as a significantExpand
  • 95
  • 3
The Human Werner Syndrome Protein Stimulates Repair of Oxidative DNA Base Damage by the DNA Glycosylase NEIL1*
The mammalian DNA glycosylase, NEIL1, specific for repair of oxidatively damaged bases in the genome via the base excision repair pathway, is activated by reactive oxygen species and preventsExpand
  • 94
  • 3
Self-promoted DNA interstrand cross-link formation by an abasic site.
The C4'-oxidized abasic site (C4-AP) is produced in DNA as a result of oxidative stress. A recent report suggests that this lesion forms interstrand cross-links. Using duplexes in which C4-AP isExpand
  • 62
  • 3
Radical and radical ion reactivity in nucleic acid chemistry
Preface to Series vii Introduction ix Contributors xi 1. Theoretical Modeling of Radiation-Induced DNA Damage 1 Anil Kumar and Michael D. Sevilla 2. Radical Reaction Pathways Initiated by DirectExpand
  • 76
  • 3
  • Open Access
Scope and mechanism of interstrand cross-link formation by the C4'-oxidized abasic site.
The C4'-oxidized abasic site (C4-AP) is a commonly formed DNA lesion, which generates two types of interstrand cross-links (ICLs). The kinetically favored cross-link consists of two full lengthExpand
  • 45
  • 2
Efficient removal of formamidopyrimidines by 8-oxoguanine glycosylases.
Under conditions of oxidative stress, the formamidopyrimidine lesions (FapyG and FapyA) are formed in competition with the corresponding 8-oxopurines (OG and OA) from a common intermediate. In orderExpand
  • 45
  • 2