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Bacterial persistence is a state in which a sub-population of dormant cells, or ‘persisters’, tolerates antibiotic treatment… Expand Aminoglycosides have been an essential component of the armamentarium in the treatment of life-threatening infections… Expand Vancomycin is a glycopeptide antibiotic that has been in clinical use for nearly 50 years as a penicillin alternative to treat… Expand Methylation of 16S ribosomal RNA (rRNA) has recently emerged as a new mechanism of resistance against aminoglycosides among gram… Expand Biofilms are adherent aggregates of bacterial cells that form on biotic and abiotic surfaces, including human tissues. Biofilms… Expand SUMMARY Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections for the past half century… Expand Aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable properties for the treatment of life… Expand Aminoglycosides have long been one of the commonest causes of drug-induced nephrotoxicity (137). Although a clear recognition of… Expand The three classes of enzymes which inactivate aminoglycosides and lead to bacterial resistance are reviewed. DNA hybridization… Expand In an examination of the relationships among plasma aminoglycoside concentrations, the minimal inhibitory concentration (MIC) for… Expand