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Enediynes

Known as: Enediyne Group, Enediynes [Chemical/Ingredient] 
Compounds with triple bonds to each side of a double bond. Many of these are CYTOTOXINS and are researched for use as CYTOTOXIC ANTIBIOTICS.
National Institutes of Health

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20'-deschloro-C-1027C 1027N1999-A2Shishijimicin A
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

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2017
2017
Conjugated Tri-Pi Systems: Investigations into Hexahapto Metal Complexes of Acyclic Conjugated Trienes and Novel Cycloaromatization Reactions of Nitrogen-Containing Enediynes
Author(s): Veccharelli, Kate | Advisor(s): O'Connor, Joseph M | Abstract: The work contained within this thesis represents… 
2015
2015
Exploration de surfaces d’énergie potentielle par modélisation moléculaire en chimie organique
Au cours de ces douze annees, au sein de differentes equipes successives, j’ai approfondi mes connaissances concernant des… 
2014
2014
Hsp 90 Inhibitor Geldanamycin Enhances the Antitumor Efficacy of Enediyne Lidamycin in Association with Reduced DNA Damage Repair
DNA repair enables tumor cells to survive from DNA damage induced by chemotherapeutic treatments or ionizing radiation (IR), and… 
2013
2013
Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes
Natural products often unite structure and function in unforeseen ways. Such facets have long driven total synthesis and drug… 
2011
2011
A novel cyclization in the construction of fused rings
The discovery of the novel thermal cyclization of enediyne molecules within the Parsons group during studies directed towards… 
Review
2011
Review
2011
Investigations into novel modes of reactivity and stereoselectivity for the cycloaromatization of conjugated enediynes and dienynes
This work begins with a review of practical cycloaromatization methodologies utilizing 1,3-dien-5-yne subunits. As a valuable… 
2009
2009
Synthesis of β-lactam fused enediynes by intramolecular kinugasa reaction: comparison of reactivity with monocyclic analogues
E-lactam fused enediynes have been successfully synthesized by intramolecular Kinugasa reaction in moderate yields. DSC studies… 
2008
2008
Enediynes and related structures in medicinal and biorganic chemistry.
2002
2002
Enediynes in 11-membered rings. Synthesis, structure, and reactivity of highly strained but unusually stable macrocycles.
The synthesis of two new aromatic cyclic enediynes 1a and 1b using a double Wittig condensation, followed by bromination and di… 
1997
1997
Synthesis and chemistry of chromoprotein antitumor antibiotics: Nine-membered enediynes are equilibrated with p-benzyne type biradicals
Abstract