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C 1027

Known as: C-1027, C1027 chromophore, C1027 chromoprotein 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

AminoglycosidesAntibiotics, AntineoplasticEnediyneslidamycin

Papers overview

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Highly Cited
2007
Highly Cited
2007
The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway.
The SgcC4 l-tyrosine 2,3-aminomutase (SgTAM) catalyzes the formation of (S)-beta-tyrosine in the biosynthetic pathway of the… 
2006
2006
The radiomimetic enediyne C-1027 induces unusual DNA damage responses to double-strand breaks.
Cells lacking the protein kinase ataxia telangiectasia mutated (ATM) have defective responses to DNA double-strand breaks (DSBs… 
2005
2005
The antitumor enediyne C-1027 alters cell cycle progression and induces chromosomal aberrations and telomere dysfunction.
This study examined the extent of chromosome instability induced in cultured human colon carcinoma HCT116 cells by the antitumor… 
Highly Cited
2003
Highly Cited
2003
Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis.
The enediyne antitumor antibiotic C-1027 contains an unusual (S)-3-chloro-4,5-dihydroxy-beta-phenylalanine moiety, which requires… 
Highly Cited
2000
Highly Cited
2000
Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein
ABSTRACT C-1027, the most potent member of the enediyne antitumor antibiotic family, is produced by Streptomyces globisporus C… 
1993
1993
Some characteristics of DNA strand scission by macromolecular antitumor antibiotic C-1027 containing a novel enediyne chromophore.
A new macromolecular antitumor antibiotic, C-1027, shows potent cytotoxic effects and DNA cutting activity. The DNA cleaving… 
1992
1992
Cloning and nucleotide sequencing of the antitumor antibiotic C-1027 apoprotein gene.
The apoprotein gene for a chromoprotein antitumor antibiotic, C-1027, was cloned from the producer strain, Streptomyces… 
Highly Cited
1990
Highly Cited
1990
Mechanism of action of a new macromolecular antitumor antibiotic, C-1027.
C-1027 is a new antitumor protein antibiotic containing a non-protein chromophore. The active moiety and the mechanism of action… 
Highly Cited
1989
Highly Cited
1989
A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity.
C-1027, a new macromolecular antitumor antibiotic produced by Streptomyces globisporus C-1027, showed extremely potent… 
Highly Cited
1988
Highly Cited
1988
A new macromolecular antitumor antibiotic, C-1027. II. Isolation and physico-chemical properties.
A new macromolecular antibiotic C-1027 was obtained from the broth filtrate of Streptomyces globisporus C-1027 by precipitation… 
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