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C 1027

Known as: C-1027, C1027 chromophore, C1027 chromoprotein 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

AminoglycosidesAntibiotics, AntineoplasticEnediyneslidamycin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis
Nonribosomal peptide synthetases (NRPSs) catalyze the biosynthesis of many biologically active peptides and typically are modular… 
2008
2008
Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism
C-1027 is an enediyne antitumor antibiotic composed of four distinct moieties: an enediyne core, a deoxy aminosugar, a β-amino… 
Highly Cited
2007
Highly Cited
2007
Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027.
C-1027 is a potent antitumor antibiotic composed of an apo-protein and a reactive enediyne chromophore. The chromophore consists… 
Highly Cited
2003
Highly Cited
2003
A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis.
The C-1027 enediyne antibiotic contains an unusual 3-chloro-4,5-dihydroxy-beta-phenylalanine moiety that is thought to be derived… 
Highly Cited
2003
Highly Cited
2003
Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis.
The enediyne antitumor antibiotic C-1027 contains an unusual (S)-3-chloro-4,5-dihydroxy-beta-phenylalanine moiety, which requires… 
Highly Cited
2000
Highly Cited
2000
Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein
ABSTRACT C-1027, the most potent member of the enediyne antitumor antibiotic family, is produced by Streptomyces globisporus C… 
1993
1993
Some characteristics of DNA strand scission by macromolecular antitumor antibiotic C-1027 containing a novel enediyne chromophore.
A new macromolecular antitumor antibiotic, C-1027, shows potent cytotoxic effects and DNA cutting activity. The DNA cleaving… 
Highly Cited
1989
Highly Cited
1989
A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity.
C-1027, a new macromolecular antitumor antibiotic produced by Streptomyces globisporus C-1027, showed extremely potent… 
Highly Cited
1988
Highly Cited
1988
A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.
Strain C-1027, an actinomycete isolated from a soil sample collected in China, was found to produce the new antibiotic, C-1027… 
Highly Cited
1988
Highly Cited
1988
A new macromolecular antitumor antibiotic, C-1027. II. Isolation and physico-chemical properties.
A new macromolecular antibiotic C-1027 was obtained from the broth filtrate of Streptomyces globisporus C-1027 by precipitation… 
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