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Arginine-rich Peptides
TLDR
Based on the fluorescence microscopic observations of mouse macrophage RAW264.7 cells, it is found that various arginine-rich peptides have a translocation activity very similar to Tat-(48–60), and the results strongly suggested the possible existence of a common internalization mechanism ubiquitous to arkinine- rich peptides. Expand
Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement.
TLDR
It is shown that the uptake of octa-arginine (R8) peptide by HeLa cells was significantly suppressed by the macropinocytosis inhibitor ethylisopropylamiloride (EIPA) and the F-actin polymerization inhibitor cytochalasin D, suggesting a role for macrop inocytotic in the uptake and suggesting that penetratin and R8 peptides have distinct internalization mechanisms. Expand
Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis.
TLDR
It is demonstrated that the membrane-associated proteoglycans are indispensable for the induction of the actin organization and the macropinocytic uptake of the arginine-rich peptides, and that HSPG is not the sole receptor for macrop inocytosis. Expand
Stearylated arginine-rich peptides: a new class of transfection systems.
TLDR
In the case of the Tat, FHV, and octaarginine peptides, N-terminal stearylation of the peptides increases the transfection efficiency by approximately 100 times to reach the same order of magnitude as that of LipofectAMINE, one of the most efficient commercially available transfections agents. Expand
Possible Existence of Common Internalization Mechanisms among Arginine-rich Peptides*
TLDR
Results strongly suggest that the arginine-rich basic peptides share a certain part of the internalization pathway. Expand
Binding of tachyplesin I to DNA revealed by footprinting analysis: significant contribution of secondary structure to DNA binding and implication for biological action.
TLDR
This is the first report on DNA interaction with a small peptide which contains a unique antiparallel beta-sheet structure and the mechanism for antimicrobial action of tachyplesin I has been inferred. Expand
Allosteric regulation of a ribozyme activity through ligand-induced conformational change.
TLDR
Interestingly, FMN addition did not influence the cleavage rate of constructs with a 5-6 bp linker but stimulated the catalytic activity of those bearing a shorter linker, suggesting that such a conformational change is a fundamental feature of allosteric enzymes in biological systems. Expand
Generation of reactive oxygen species and activation of NF‐κB by non‐Aβ component of Alzheimer's disease amyloid
TLDR
It is suggested that NAC fibrils increase mitochondrial ROS generation and activate NF‐κB, thereby causing a differential change in gene expression between neurons and astrocytes in the AD brain. Expand
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