lidamycin
National Institutes of Health
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CD13 is a marker of angiogenic endothelial cells, and recently it is proved to be a biomarker of human liver cancer stem cells…
Lidamycin (LDM) is a novel member of the enediyne antibiotics identified in China with potent antitumor activity. However, it…
Aim:To assess the synergistic actions of lidamycin (LDM) and chloroquine (CQ), a lysosomal enzyme inhibitor, in human non-small…
Recent advances in cell cycle regulation have led to a suggestion of therapeutically targeting cell cycle checkpoint pathways in…
Enediyne compound is one class of antibiotics with very potent anti-cancer activity. However, the role of p53 in enediyne…
AIM
To study the in vitro and in vivo antitumor effect of lidamycin (LDM) on hepatoma and the active moiety of its molecule…
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Type IV collagenase including MMP-2 and -9 plays an important role in cancer cell invasion and metastasis and is an…
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To study the antitumor effects of an immunoconjugate composed of lidamycin (LDM) and monoclonal antibody 3G11 (3G11-LDM…
Mitotic cell death, a different cell death mode from apoptosis, has been focused on in tumor therapy. It may involve the…