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Pumilacidin, a complex of new antiviral antibiotics. Production, isolation, chemical properties, structure and biological activity.
New antibiotic pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K(+)-ATPase and demonstrated antiulcer activity in rat.
PUMILACIDIN, A COMPLEX OF NEW ANTIVIRAL ANTIBIOTICS
Pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K+-ATPase and demonstrated antiulcer activity in rat.
Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity.
New anthracycline antibiotics have been isolated from the culture of Streptomyces galilaeus MA144-M1 and aclacinomycin-A showed the strongest activity in inhibiting leukemia L-1210 and had lower toxicity than others.
New anthracycline antibiotic aclacinomycin A: experimental studies and correlations with clinical trials.
- T. Oki, T. Takeuchi, S. Oka, H. Umezawa
- ChemistryRecent results in cancer research. Fortschritte…
An anthracyclic antibiotic linked to the aminosugar L-rhodosamine and to two other deoxysugars, 2-deoxy-L-fucose and L-cinerulose A is described.
Pradimicin A, a Carbohydrate-Binding Nonpeptidic Lead Compound for Treatment of Infections with Viruses with Highly Glycosylated Envelopes, Such as Human Immunodeficiency Virus
Pradimicin A represents the first prototype compound of a nonpeptidic CBA lead and belongs to a conceptually novel type of potential therapeutics for which drug pressure results in the selection of glycan deletions in the HIV gp120 envelope.
Entry of hepatitis C virus and human immunodeficiency virus is selectively inhibited by carbohydrate-binding agents but not by polyanions.
The structure of pradimicins A, B and C: a novel family of antifungal antibiotics
High-resolution solution structure of siamycin II: Novel amphipathic character of a 21-residue peptide that inhibits HIV fusion
The amphipathic nature of siamycin II and siamYcin I suggests that a polar (or apolar) site on the target protein may be masked by the apolar face of the peptide upon peptide/protein complexation.
Anicequol, a novel inhibitor for anchorage-independent growth of tumor cells from Penicillium aurantiogriseum Dierckx TP-F0213.
A novel inhibitor for anchorage-independent growth of tumor cells was isolated from the culture broth of a fungal strain and inhibition of human colon cancer DLD-1 cells with the IC50 of 1.2 microM was inhibited.
Arylsulfatase from Streptomyces griseorubiginosus S980-14.
- T. Ueki, Y. Sawada, Y. Fukagawa, T. Oki
- Chemistry, BiologyBioscience, biotechnology, and biochemistry
- 23 June 1995
A new arylsulfatase designated Es-1, which desulfated etoposide 4'-sulfate and p-nitrophenyl sulfate, was isolated from Streptomyces griseorubiginosus S980-14 and purified to protein homogeneity by…