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Pumilacidin, a complex of new antiviral antibiotics. Production, isolation, chemical properties, structure and biological activity.
New antibiotic pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K(+)-ATPase and demonstrated antiulcer activity in rat. Expand
PUMILACIDIN, A COMPLEX OF NEW ANTIVIRAL ANTIBIOTICS
Pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K+-ATPase and demonstrated antiulcer activity in rat. Expand
Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity.
New anthracycline antibiotics have been isolated from the culture of Streptomyces galilaeus MA144-M1 and aclacinomycin-A showed the strongest activity in inhibiting leukemia L-1210 and had lower toxicity than others. Expand
New anthracycline antibiotic aclacinomycin A: experimental studies and correlations with clinical trials.
An anthracyclic antibiotic linked to the aminosugar L-rhodosamine and to two other deoxysugars, 2-deoxy-L-fucose and L-cinerulose A is described. Expand
Pradimicin A, a Carbohydrate-Binding Nonpeptidic Lead Compound for Treatment of Infections with Viruses with Highly Glycosylated Envelopes, Such as Human Immunodeficiency Virus
- J. Balzarini, K. Van Laethem, +6 authors D. Schols
- Biology, Medicine
- Journal of Virology
- 18 October 2006
Pradimicin A represents the first prototype compound of a nonpeptidic CBA lead and belongs to a conceptually novel type of potential therapeutics for which drug pressure results in the selection of glycan deletions in the HIV gp120 envelope. Expand
Entry of hepatitis C virus and human immunodeficiency virus is selectively inhibited by carbohydrate-binding agents but not by polyanions.
Polyanions such as dextran sulfate-5000 and sulfated polyvinylalcohol inhibited HIV entry but were devoid of any activity against HCV infection, indicating that they act through a different mechanism. Expand
The structure of pradimicins A, B and C: a novel family of antifungal antibiotics
High-resolution solution structure of siamycin II: Novel amphipathic character of a 21-residue peptide that inhibits HIV fusion
- K. Constantine, M. Friedrichs, +9 authors L. Mueller
- Chemistry, Medicine
- Journal of biomolecular NMR
- 1 April 1995
The amphipathic nature of siamycin II and siamYcin I suggests that a polar (or apolar) site on the target protein may be masked by the apolar face of the peptide upon peptide/protein complexation. Expand
Anicequol, a novel inhibitor for anchorage-independent growth of tumor cells from Penicillium aurantiogriseum Dierckx TP-F0213.
A novel inhibitor for anchorage-independent growth of tumor cells was isolated from the culture broth of a fungal strain and inhibition of human colon cancer DLD-1 cells with the IC50 of 1.2 microM was inhibited. Expand
Arylsulfatase from Streptomyces griseorubiginosus S980-14.
- T. Ueki, Y. Sawada, Y. Fukagawa, T. Oki
- Medicine, Chemistry
- Bioscience, biotechnology, and biochemistry
- 23 June 1995
A new arylsulfatase designated Es-1, which desulfated etoposide 4'-sulfate and p-nitrophenyl sulfate, was isolated from Streptomyces griseorubiginosus S980-14 and purified to protein homogeneity by… Expand