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alpha-Synuclein

Known as: Non-A4 Component of Amyloid Precursor, Non-AB Component of AD Amyloid Protein, NACP 
Alpha-synuclein (140 aa, ~14 kDa) is encoded by the human SNCA gene. This protein plays a role in the modulation of presynaptic vesicle transport and… 
National Institutes of Health

Related topics

Related topics

25 relations
Alpha synuclein Ag:PrThr:Pt:Tiss:Ord:Immune stainAlzheimer's DiseaseAlzheimer's Disease Pathway KEGGApoptosis

Narrower (1)

PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder)

Broader (1)

Synucleins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.
Alpha-synuclein and cysteine-string protein-alpha (CSPalpha) are abundant synaptic vesicle proteins independently linked to… 
Highly Cited
2005
Highly Cited
2005
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.
Abnormal biology of alpha-synuclein (alpha-Syn) is directly implicated in the pathogenesis of Parkinson's disease and other alpha… 
Highly Cited
2002
Highly Cited
2002
Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.
Two mutations in the protein alpha-synuclein (A30P and A53T) are linked to an autosomal dominant form of Parkinson's disease… 
Highly Cited
2002
Highly Cited
2002
Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.
The Parkinson's disease substantia nigra is characterized by the loss of dopaminergic neurons and the presence of cytoplasmic… 
Highly Cited
2000
Highly Cited
2000
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
Two missense mutations in the gene encoding alpha-synuclein have been linked to rare, early-onset forms of Parkinson's disease… 
Highly Cited
2000
Highly Cited
2000
Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation.
Filamentous inclusions made of alpha-synuclein constitute the defining neuropathological characteristic of Parkinson's disease… 
Highly Cited
2000
Highly Cited
2000
alpha-synuclein promotes mitochondrial deficit and oxidative stress.
Abnormal accumulation of the presynaptic protein alpha-synuclein has recently been implicated in the pathogenesis of Alzheimer's… 
Highly Cited
2000
Highly Cited
2000
MPTP induces alpha‐synuclein aggregation in the substantia nigra of baboons
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity reproduces many of the features of Parkinson's disease (PD… 
Review
1998
Review
1998
The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
Highly Cited
1994
Highly Cited
1994
Identification of two distinct synucleins from human brain
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