alpha-Synuclein

Known as: Non-A4 Component of Amyloid Precursor, Non-AB Component of AD Amyloid Protein, NACP 
Alpha-synuclein (140 aa, ~14 kDa) is encoded by the human SNCA gene. This protein plays a role in the modulation of presynaptic vesicle transport and… (More)

Topic mentions per year

Topic mentions per year

1987-2018
010020019872018

Papers overview

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Review
2017
Review
2017
Two of the most devastating neurodegenerative diseases are consequences out of misfolding and aggregation of key proteins-alpha… (More)
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Review
2016
Review
2016
The pharmacological treatment of Parkinson's disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not… (More)
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Highly Cited
2009
Highly Cited
2009
Neuronal accumulation of alpha-synuclein and Lewy body formation are characteristic to many neurodegenerative diseases, including… (More)
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Highly Cited
2004
Highly Cited
2004
Aberrant alpha-synuclein degradation is implicated in Parkinson's disease pathogenesis because the protein accumulates in the… (More)
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Highly Cited
2004
Highly Cited
2004
Genomic triplication of the alpha-synuclein gene (SNCA) has been reported to cause hereditary early-onset parkinsonism with… (More)
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Highly Cited
2002
Highly Cited
2002
The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a… (More)
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Highly Cited
2000
Highly Cited
2000
To elucidate the role of the synaptic protein alpha-synuclein in neurodegenerative disorders, transgenic mice expressing wild… (More)
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Highly Cited
2000
Highly Cited
2000
alpha-Synuclein (alpha-Syn) is a 14 kDa protein of unknown function that has been implicated in the pathophysiology of Parkinson… (More)
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Highly Cited
1998
Highly Cited
1998
Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy… (More)
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Highly Cited
1997
Highly Cited
1997
Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approximately 2 percent. A pattern… (More)
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