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alpha-Synuclein

Known as: Non-A4 Component of Amyloid Precursor, Non-AB Component of AD Amyloid Protein, NACP 
Alpha-synuclein (140 aa, ~14 kDa) is encoded by the human SNCA gene. This protein plays a role in the modulation of presynaptic vesicle transport and… 
National Institutes of Health

Related topics

Related topics

25 relations
Alpha synuclein Ag:PrThr:Pt:Tiss:Ord:Immune stainAlzheimer's DiseaseAlzheimer's Disease Pathway KEGGApoptosis

Narrower (1)

PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder)

Broader (1)

Synucleins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.
OBJECTIVE Parkinson's disease (PD) is a neurodegenerative condition that typically presents as a movement disorder but is known… 
Highly Cited
2005
Highly Cited
2005
Familial Parkinson's disease: Clinical and genetic analysis of four Basque families
During the last few years several loci have been linked to Mendelian forms of Parkinson's disease (PD). To date, 5 causative… 
Highly Cited
2004
Highly Cited
2004
Protective effect of TAT‐delivered α‐synuclein: relevance of the C‐terminal domain and involvement of HSP70
α‐Synuclein (α‐syn) is a 140‐amino acid presinaptic protein whose mutations A30P and A53T have been linked to familiar Parkinson… 
Review
2004
Review
2004
A critical review of the development and importance of proteinaceous aggregates in animal models of Parkinson's disease: new insights into Lewy body formation.
Highly Cited
2004
Highly Cited
2004
Beta-synuclein gene alterations in dementia with Lewy bodies.
OBJECTIVE To determine whether mutations in the genes for alpha-synuclein or beta-synuclein are responsible for dementia with… 
Highly Cited
2004
Highly Cited
2004
Inhibition of fibril formation and toxicity of a fragment of α-synuclein by an N-methylated peptide analogue
Highly Cited
2003
Highly Cited
2003
Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies.
Alpha-synuclein (alphaS) is an abundant neuronal protein that accumulates in insoluble inclusions in Parkinson's disease (PD) and… 
Highly Cited
2002
Highly Cited
2002
Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro.
We examined the effect of methionine oxidation of human recombinant alpha-synuclein on its structural properties and propensity… 
Highly Cited
2000
Highly Cited
2000
Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation
Established methodology for the preparation of peptide thioesters requires the use of t‐butoxycarbonyl chemistry owing to the… 
Highly Cited
1998
Highly Cited
1998
Degenerative terminals of the perforant pathway are human α-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease
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