Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

alpha-Synuclein

Known as: Non-A4 Component of Amyloid Precursor, Non-AB Component of AD Amyloid Protein, NACP 
Alpha-synuclein (140 aa, ~14 kDa) is encoded by the human SNCA gene. This protein plays a role in the modulation of presynaptic vesicle transport and… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related neurodegenerative disorders, affecting… Expand
Is this relevant?
Review
2019
Review
2019
Humans evolved a symbiotic relationship with their gut microbiome, a complex microbial community composed of bacteria, archaea… Expand
  • figure 1
Is this relevant?
Review
2018
Review
2018
The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-associated tau protein characterizes 80… Expand
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Familial parkinsonism and dementia with cortical and subcortical Lewy bodies is uncommon, and no genetic defect has been reported… Expand
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Aberrant alpha-synuclein degradation is implicated in Parkinson's disease pathogenesis because the protein accumulates in the… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Aggregated alpha-synuclein proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies, and oxidative… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
To elucidate the role of the synaptic protein alpha-synuclein in neurodegenerative disorders, transgenic mice expressing wild… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The Parkinson's disease (PD) substantia nigra is characterized by the presence of Lewy bodies containing fibrillar alpha… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Lewy bodies (LBs) are hallmark lesions of degenerating neurons in the brains of patients with Parkinson's disease (PD) and… Expand
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy… Expand
Is this relevant?