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Diagnosis and management of dementia with Lewy bodies
TLDR
The authors propose a new scheme for the pathologic assessment of LBs and Lewy neurites (LN) using alpha-synuclein immunohistochemistry and semiquantitative grading of lesion density, with the pattern of regional involvement being more important than total LB count. Expand
MDS clinical diagnostic criteria for Parkinson's disease
TLDR
The Movement Disorder Society PD Criteria retain motor parkinsonism as the core feature of the disease, defined as bradykinesia plus rest tremor or rigidity, and two levels of certainty are delineated: clinically established PD and probable PD. Expand
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
TLDR
The aim of this study was to improve the neuropathologic recognition and provide criteria for the pathological diagnosis in the neurodegenerative diseases grouped as frontotemporal lobar degeneration (FTLD) and incorporate up-to-date neuropathology in the light of recent immunohistochemical, biochemical, and genetic advances. Expand
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update
TLDR
A system of nosology was introduced that grouped the FTLD subtypes into broad categories, based on the molecular defect that is most characteristic, according to current evidence, and provided a concise and consistent terminology that has now been widely adopted in the literature. Expand
Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity
TLDR
The VTA contains the A10 group of DA containing neurons, which have been grouped into nuclei to be found on the floor of the midbrain tegmentum--Npn, Nif, Npbp and Nln rostralis and caudalis and the role of the VTA as a mediator of dialogue with the frontostriatal and limbic/extrapyramidal system is discussed. Expand
The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
TLDR
After 20 years follow-up of newly diagnosed patients with Parkinson's disease (PD), 100 of 136 (74%) have died and 17 people with dementia had postmortems, while others had mixed neuropathology. Expand
The cerebral cortex is damaged in chronic alcoholics
TLDR
The selective frontal neurodegeneration and the frontal focus of white matter atrophy are supported by neuropsychological, regional blood flow, and magnetic resonance imaging studies of frontal lobe dysfunction in chronic alcoholics and may correlate with abnormalities in working memory. Expand
Disease duration and the integrity of the nigrostriatal system in Parkinson's disease.
TLDR
The extent of nigrostriatal degeneration in patients with Parkinson's disease at different disease durations from time of diagnosis is investigated and loss of dopaminergic markers in the dorsal putamen occurs rapidly and is virtually complete by 4 years post-diagnosis. Expand
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
TLDR
It is found that FTLD-TDP associates with multiple SNPs mapping to a single linkage disequilibrium block on 7p21 that contains TMEM 106B, which implicate variants in TMEM106B as a strong risk factor for FTLD, suggesting an underlying pathogenic mechanism. Expand
Diagnosis and management of dementia with Lewy bodies
The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use forExpand
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