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Agmatine: an endogenous clonidine-displacing substance in the brain.
- G. Li, S. Regunathan, C. Barrow, J. Eshraghi, R. Cooper, D. Reis
- Chemistry, Medicine
- 18 February 1994
Clonidine, an antihypertensive drug, binds to alpha 2-adrenergic and imidazoline receptors. The endogenous ligand for imidazoline receptors may be a clonidine-displacing substance, a small molecule… Expand
Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits*
- C. Curtain, F. Ali, +7 authors K. Barnham
- Biology, Medicine
- The Journal of Biological Chemistry
- 27 March 2001
Amyloid β peptide (Aβ) is the major constituent of extracellular plaques and perivascular amyloid deposits, the pathognomonic neuropathological lesions of Alzheimer's disease. Cu2+ and Zn2+ bind Aβ,… Expand
Incubators: A Realist's Guide to the World's New Business Accelerators
- C. Barrow
- 15 December 1998
Introduction. PART ONE: A BRIEF HISTORY OF BUSINESS INCUBATION. How Business Incubators Work. How it All Began. Who Goes in for Incubation? PART TWO: WHO ARE THE PLAYERS? The Property Developers.… Expand
Isolation and characterization of polyunsaturated fatty acid producing Thraustochytrium species: screening of strains and optimization of omega-3 production
- A. Burja, Helia Radianingtyas, A. Windust, C. Barrow
- Medicine, Biology
- Applied Microbiology and Biotechnology
- 20 April 2006
An isolation program targeting Thraustochytrids (marine fungoid protists) from 19 different Atlantic Canadian locations was performed. Sixty-eight isolates were screened for biomass, total fatty acid… Expand
Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition.
The secondary structures in solution of the synthetic, naturally occurring, amyloid beta peptides, residues 1 to 42 [beta (1-42)] and beta (1-39), and related fragments, beta (1-28) and beta (29-42),… Expand
A Simple 96-Well Microplate Method for Estimation of Total Polyphenol Content in Seaweeds
- Qing Zhang, J. Zhang, J. Shen, A. Silva, D. Dennis, C. Barrow
- Journal of Applied Phycology
- 26 July 2006
Seaweed polyphenols are potent antioxidants and have also been shown to have α-glucosidase inhibiting activity. In our continuous efforts to develop new marine-based nutraceuticals and functional… Expand
Biochar: Potential for countering land degradation and for improving agriculture
- C. Barrow
- 1 May 2012
Biochar is attracting attention as a means for sequestering carbon and as a potentially valuable input for agriculture to improve soil fertility, aid sustainable production and reduce contamination… Expand
Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra.
- C. Barrow, A. Yasuda, P. T. Kenny, M. Zagorski
- Chemistry, Medicine
- Journal of molecular biology
- 1 June 1992
The A4 or beta-peptide (39 to 43 amino acid residues) is the principal proteinaceous component of amyloid deposits in Alzheimer's disease. Using circular dichroism (c.d.), we have studied the… Expand
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.
The abnormal form of the prion protein (PrP) is believed to be responsible for the transmissible spongiform encephalopathies. A peptide encompassing residues 106-126 of human PrP (PrP106-126) is… Expand
Enzyme-assisted extraction of bioactives from plants.
Demand for new and novel natural compounds has intensified the development of plant-derived compounds known as bioactives that either promote health or are toxic when ingested. Enhanced release of… Expand