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Agmatine: an endogenous clonidine-displacing substance in the brain.
Clonidine, an antihypertensive drug, binds to alpha 2-adrenergic and imidazoline receptors. The endogenous ligand for imidazoline receptors may be a clonidine-displacing substance, a small moleculeExpand
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Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits*
Amyloid β peptide (Aβ) is the major constituent of extracellular plaques and perivascular amyloid deposits, the pathognomonic neuropathological lesions of Alzheimer's disease. Cu2+ and Zn2+ bind Aβ,Expand
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Incubators: A Realist's Guide to the World's New Business Accelerators
Introduction. PART ONE: A BRIEF HISTORY OF BUSINESS INCUBATION. How Business Incubators Work. How it All Began. Who Goes in for Incubation? PART TWO: WHO ARE THE PLAYERS? The Property Developers.Expand
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Isolation and characterization of polyunsaturated fatty acid producing Thraustochytrium species: screening of strains and optimization of omega-3 production
An isolation program targeting Thraustochytrids (marine fungoid protists) from 19 different Atlantic Canadian locations was performed. Sixty-eight isolates were screened for biomass, total fatty acidExpand
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Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition.
The secondary structures in solution of the synthetic, naturally occurring, amyloid beta peptides, residues 1 to 42 [beta (1-42)] and beta (1-39), and related fragments, beta (1-28) and beta (29-42),Expand
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A Simple 96-Well Microplate Method for Estimation of Total Polyphenol Content in Seaweeds
Seaweed polyphenols are potent antioxidants and have also been shown to have α-glucosidase inhibiting activity. In our continuous efforts to develop new marine-based nutraceuticals and functionalExpand
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Biochar: Potential for countering land degradation and for improving agriculture
Biochar is attracting attention as a means for sequestering carbon and as a potentially valuable input for agriculture to improve soil fertility, aid sustainable production and reduce contaminationExpand
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Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra.
The A4 or beta-peptide (39 to 43 amino acid residues) is the principal proteinaceous component of amyloid deposits in Alzheimer's disease. Using circular dichroism (c.d.), we have studied theExpand
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Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.
The abnormal form of the prion protein (PrP) is believed to be responsible for the transmissible spongiform encephalopathies. A peptide encompassing residues 106-126 of human PrP (PrP106-126) isExpand
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Enzyme-assisted extraction of bioactives from plants.
Demand for new and novel natural compounds has intensified the development of plant-derived compounds known as bioactives that either promote health or are toxic when ingested. Enhanced release ofExpand
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