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‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease
Why dopamine-containing neurons of the brain’s substantia nigra pars compacta die in Parkinson’s disease has been an enduring mystery. Our studies suggest that the unusual reliance of these neuronsExpand
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  • Open Access
Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is widely used to induce an animal model of Parkinsonism. The conventional mouse model, which usually involves acute or subacute injections ofExpand
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Immunocytochemical characterization of catecholaminergic neurons in the rat striatum following dopamine‐depleting lesions
It is possible either permanently or transiently to deplete the rat striatum of dopamine. Following such depletions, striatal neurons immunoreactive for tyrosine hydroxylase (TH), aromatic l‐aminoExpand
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The Synaptic Framework for Chemical Signaling in Nucleus Accumbens
  • G. Meredith
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1 June 1999
ABSTRACT: Our knowledge of the organization of the nucleus accumbens has been greatly advanced in the last two decades, but only now are we beginning to understand the complex neural circuitry thatExpand
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Prominent Activation of Brainstem and Pallidal Afferents of the Ventral Tegmental Area by Cocaine
Blockade of monoamine transporters by cocaine should not necessarily lead to certain observed consequences of cocaine administration, including increased firing of ventral mesencephalic dopamine (DA)Expand
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Animal models of Parkinson’s disease progression
Parkinson’s disease (PD) is a progressive neurodegenerative disorder whose etiology is not understood. This disease occurs both sporadically and through inheritance of single genes, although theExpand
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Aberrant Restoration of Spines and their Synapses in l-DOPA-Induced Dyskinesia: Involvement of Corticostriatal but Not Thalamostriatal Synapses
We examined the structural plasticity of excitatory synapses from corticostriatal and thalamostriatal pathways and their postsynaptic targets in adult Sprague-Dawley rats to understand how theseExpand
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  • Open Access
Brain-derived neurotrophic factor expression is increased in the rat amygdala, piriform cortex and hypothalamus following repeated amphetamine administration
The amygdala plays an important role in the regulation of motivational states, especially those associated with addiction. The amygdala also expresses high levels of brain-derived neurotrophic factorExpand
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The structural basis for mapping behavior onto the ventral striatum and its subdivisions
The striatum can be divided into dorsal (caudate-putamen) and ventral parts. In the ventral division, the nucleus accumbens, which subserves adaptive and goal-directed behaviors, is furtherExpand
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Fos After Single and Repeated Self-Administration of Cocaine and Saline in the Rat: Emphasis on the Basal Forebrain and Recalibration of Expression
The effects of addictive psychostimulant drugs on the brain change over repeated administrations. We evaluated a large sample of brain structures, particularly ones comprising basal forebrainExpand
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