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‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease
Why dopamine-containing neurons of the brain’s substantia nigra pars compacta die in Parkinson’s disease has been an enduring mystery. Our studies suggest that the unusual reliance of these neurons…
Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment
Immunocytochemical characterization of catecholaminergic neurons in the rat striatum following dopamine‐depleting lesions
- G. Meredith, T. Farrell, P. Kellaghan, Y. Tan, D. S. Zahm, S. Totterdell
- BiologyThe European journal of neuroscience
- 1 October 1999
It is established that after unilateral 6‐hydroxydopamine lesions or methamphetamine administration, striatal TH‐immunoreactive neurons differ in size, morphology and location from those that are immunopositive for AADC or dopamine.
The Synaptic Framework for Chemical Signaling in Nucleus Accumbens
- G. Meredith
- BiologyAnnals of the New York Academy of Sciences
- 1 June 1999
It is shown that psychostimulants, dopamine‐deleting lesions, and chronic blockade of dopaminergic receptors can alter the anatomical substrate, synaptology, and neurotrophic factors that govern circuits through the shell and core.
Prominent Activation of Brainstem and Pallidal Afferents of the Ventral Tegmental Area by Cocaine
It is concluded that a previously unappreciated activation of pallidal and brainstem afferents may contribute to the modulation of dopaminergic neuronal activity following cocaine administration.
MPTP mouse models of Parkinson's disease: an update.
The ability of MPTP mouse models to replicate the pathophysiology of PD, the mechanisms ofMPTP-induced neurotoxicity, strain differences in susceptibility to MPTP, and the models' roles in testing therapeutic approaches are discussed.
Animal models of Parkinson’s disease progression
This review critically evaluates in vivo models and the roles they play in mimicking the progression of PD and indicates that toxin-induced and genetically manipulated models are critical for the development of neuroprotective strategies.
Fos After Single and Repeated Self-Administration of Cocaine and Saline in the Rat: Emphasis on the Basal Forebrain and Recalibration of Expression
Self-administered cocaine mainly elicits Fos expression, which persists or increases with repeated administrations in some structures, but declines in others, and Fosexpression is sensitized in most extended amygdala structures merely by the act of repeated self-administering.
The structural basis for mapping behavior onto the ventral striatum and its subdivisions
- G. Meredith, B. Baldo, Matthew E. Andrezjewski, A. Kelley
- Biology, PsychologyBrain Structure and Function
- 7 February 2008
This review is focused on evaluating the structural differences in nucleus accumbens core and shell neurons and discusses how such different morphologies could underlie distinguishable behavioral processes.