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The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization
Many copies of mammalian mitochondrial DNA contain a short triple-stranded region, or displacement loop (D-loop), in the major noncoding region. In the 35 years since their discovery, no function hasExpand
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Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation
Established methodology for the preparation of peptide thioesters requires the use of t‐butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in FmocExpand
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Application of 2‐D free‐flow electrophoresis/RP‐HPLC for proteomic analysis of human plasma depleted of multi high‐abundance proteins
Free‐flow electrophoresis (FFE) and rapid (6 min) RP‐HPLC was used to fractionate human citrate‐treated plasma. Prior to analysis, the six most abundant proteins in plasma were removed byExpand
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The amyloid‐β peptide and its role in Alzheimer's disease
Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid‐β (Aβ) peptide, which is currently the subject ofExpand
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Amyloid-beta as a "difficult sequence" in solid phase peptide synthesis.
The phenomenon of "difficult sequence" has long frustrated chemists in their efforts to assemble peptides that contain such sequences by solid phase synthesis methods. A variety of remedial measuresExpand
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Amyloid-β as a “Difficult Sequence” in Solid Phase Peptide Synthesis
The phenomenon of “difficult sequence” has long frustrated chemists in their efforts to assemble peptides that contain such sequences by solid phase synthesis methods. A variety of remedial measuresExpand
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Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes.
A biosensor-based micro-affinity purification method to recover protein binding partners and their complexes for down stream proteomics analysis has been developed using the BIAcore 3000 fitted withExpand
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Synthesis and secondary structural studies of penta(acetyl-Hmb)A beta(1-40).
The Fmoc solid phase synthesis of A beta(1-40), a strongly aggregating peptide found in Alzheimer's disease brain, was performed using 2-hydroxy-4-methoxybenzyl (Hmb) backbone amide protection.Expand
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The amyloid-beta peptide and its role in Alzheimer's disease.
Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid-beta (A beta) peptide, which is currently the subject ofExpand
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Aβ peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture
The major constituent of amyloid plaques in the Alzheimer disease (AD) brain is the amyloid protein (Aβ). Aβ has been shown to be neurotoxic to cells, but the exact mechanism of its effects are stillExpand
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