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The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization
- J. He, Chih-Chieh Mao, +11 authors I. Holt
- Medicine, Biology
- The Journal of cell biology
- 15 January 2007
Many copies of mammalian mitochondrial DNA contain a short triple-stranded region, or displacement loop (D-loop), in the major noncoding region. In the 35 years since their discovery, no function has… Expand
Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation
- A. Clippingdale, C. Barrow, J. Wade
- Chemistry, Medicine
- Journal of peptide science : an official…
- 1 May 2000
Established methodology for the preparation of peptide thioesters requires the use of t‐butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in Fmoc… Expand
Application of 2‐D free‐flow electrophoresis/RP‐HPLC for proteomic analysis of human plasma depleted of multi high‐abundance proteins
Free‐flow electrophoresis (FFE) and rapid (6 min) RP‐HPLC was used to fractionate human citrate‐treated plasma. Prior to analysis, the six most abundant proteins in plasma were removed by… Expand
The amyloid‐β peptide and its role in Alzheimer's disease
Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid‐β (Aβ) peptide, which is currently the subject of… Expand
Amyloid-beta as a "difficult sequence" in solid phase peptide synthesis.
The phenomenon of "difficult sequence" has long frustrated chemists in their efforts to assemble peptides that contain such sequences by solid phase synthesis methods. A variety of remedial measures… Expand
Amyloid-β as a “Difficult Sequence” in Solid Phase Peptide Synthesis
The phenomenon of “difficult sequence” has long frustrated chemists in their efforts to assemble peptides that contain such sequences by solid phase synthesis methods. A variety of remedial measures… Expand
Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes.
- B. Catimel, J. Rothacker, +6 authors E. Nice
- Biology, Medicine
- Journal of proteome research
- 9 August 2005
A biosensor-based micro-affinity purification method to recover protein binding partners and their complexes for down stream proteomics analysis has been developed using the BIAcore 3000 fitted with… Expand
Synthesis and secondary structural studies of penta(acetyl-Hmb)A beta(1-40).
- A. Clippingdale, M. Macris, J. Wade, C. Barrow
- Medicine, Chemistry
- The journal of peptide research : official…
- 1 June 1999
The Fmoc solid phase synthesis of A beta(1-40), a strongly aggregating peptide found in Alzheimer's disease brain, was performed using 2-hydroxy-4-methoxybenzyl (Hmb) backbone amide protection.… Expand
The amyloid-beta peptide and its role in Alzheimer's disease.
Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid-beta (A beta) peptide, which is currently the subject of… Expand
Aβ peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture
- S. Mok, A. Clippingdale, K. Beyreuther, C. Masters, C. Barrow, D. Small
- Biology, Medicine
- Journal of neuroscience research
- 15 August 2000
The major constituent of amyloid plaques in the Alzheimer disease (AD) brain is the amyloid protein (Aβ). Aβ has been shown to be neurotoxic to cells, but the exact mechanism of its effects are still… Expand