• Publications
  • Influence
Alzheimer's disease.
  • D. Selkoe
  • Medicine
  • Cold Spring Harbor perspectives in biology
  • 2011
Over the last three decades, advances in biochemical pathology and human genetics have illuminated one of the most enigmatic subjects in biomedicine--neurodegeneration. Eponymic diseases of theExpand
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques in brain tissue.Expand
Alzheimer's disease: genes, proteins, and therapy.
  • D. Selkoe
  • Biology, Medicine
  • Physiological reviews
  • 1 April 2001
Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has arisen from the application of molecular and cell biology to this complex disorder of the limbic and associationExpand
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
Although extensive data support a central pathogenic role for amyloid β protein (Aβ) in Alzheimer's disease, the amyloid hypothesis remains controversial, in part because a specific neurotoxicExpand
Alzheimer's Disease Is a Synaptic Failure
In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations ofExpand
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
  • C. Haass, D. Selkoe
  • Chemistry, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 February 2007
The distinct protein aggregates that are found in Alzheimer's, Parkinson's, Huntington's and prion diseases seem to cause these disorders. Small intermediates — soluble oligomers — in the aggregationExpand
The amyloid hypothesis of Alzheimer's disease at 25 years
Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production andExpand
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Alzheimer's disease constitutes a rising threat to public health. Despite extensive research in cellular and animal models, identifying the pathogenic agent present in the human brain and showingExpand
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging-Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD)Expand
Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway
Alzheimer's disease (AD) is characterized by decreased synapse density in hippocampus and neocortex, and synapse loss is the strongest anatomical correlate of the degree of clinical impairment.Expand