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Natively unfolded proteins: A point where biology waits for physics
- V. Uversky
- Chemistry, Medicine
- Protein science : a publication of the Protein…
- 1 April 2002
The experimental material accumulated in the literature on the conformational behavior of intrinsically unstructured (natively unfolded) proteins was analyzed. Results of this analysis showed that… Expand
PONDR-FIT: a meta-predictor of intrinsically disordered amino acids.
- B. Xue, Roland L. Dunbrack, R. Williams, A. Dunker, V. Uversky
- Medicine, Biology
- Biochimica et biophysica acta
- 1 April 2010
Protein intrinsic disorder is becoming increasingly recognized in proteomics research. While lacking structure, many regions of disorder have been associated with biological function. There are many… Expand
Why are “natively unfolded” proteins unstructured under physiologic conditions?
“Natively unfolded” proteins occupy a unique niche within the protein kingdom in that they lack ordered structure under conditions of neutral pH in vitro. Analysis of amino acid sequences, based on… Expand
DisProt: the Database of Disordered Proteins
- Megan Sickmeier, J. A. Hamilton, +9 authors A. Dunker
- Medicine, Biology
- Nucleic Acids Res.
- 1 December 2006
The Database of Protein Disorder (DisProt) links structure and function information for intrinsically disordered proteins (IDPs). Intrinsically disordered proteins do not form a fixed… Expand
Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism.
In the search for the molecular mechanism of insulin fibrillation, the kinetics of insulin fibril formation were studied under different conditions using the fluorescent dye thioflavin T (ThT). The… Expand
Evidence for a Partially Folded Intermediate in α-Synuclein Fibril Formation*
Intracellular proteinaceous aggregates (Lewy bodies and Lewy neurites) of α-synuclein are hallmarks of neurodegenerative diseases such as Parkinson's disease, dementia with Lewy bodies, and multiple… Expand
What does it mean to be natively unfolded?
- V. Uversky
- Medicine, Chemistry
- European journal of biochemistry
Natively unfolded or intrinsically unstructured proteins constitute a unique group of the protein kingdom. The evolutionary persistence of such proteins represents strong evidence in the favor of… Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the… Expand
Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure.
Parkinson's disease involves the aggregation of alpha-synuclein to form fibrils, which are the major constituent of intracellular protein inclusions (Lewy bodies and Lewy neurites) in dopaminergic… Expand
Classification of Intrinsically Disordered Regions and Proteins
1.1. Uncharacterized Protein Segments Are a Source of Functional Novelty Over the past decade, we have observed a massive increase in the amount of information describing protein sequences from a… Expand