• Publications
  • Influence
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
TLDR
New cellular and molecular mechanisms for the resolution of inflammation are presented, revealing key roles for eicosanoids, such as lipoxins, and recently discovered families of endogenous chemical mediators, termed resolvins and protectins, which have anti-inflammatory and pro-resolution properties.
Pro-resolving lipid mediators are leads for resolution physiology
TLDR
The mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions are covered.
Resolution of inflammation: the beginning programs the end
TLDR
Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins, and the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways.
Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.
TLDR
It is reported that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and docosahexaenoic acid produce a novel family of bioactive 17R-hydroxy-containing di- and tri-Hydroxy-docosanoids termed resolvins.
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family
TLDR
An International Union of Basic and Clinical Pharmacology (IUPHAR)-recommended nomenclature is introduced and unmet challenges are discussed, including the mechanisms used by these receptors to bind diverse ligands and mediate different biological functions.
TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein
TLDR
A profilin-like molecule from the protozoan parasite Toxoplasma gondii is identified that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88 and is the first chemically defined ligand for this TLR.
Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing
TLDR
It is reported that inflammatory exudates from mice treated with ω-3 polyunsaturated fatty acid and aspirin (ASA) generate a novel array of bioactive lipid signals, which provides a novel mechanism for the therapeutic benefits ofπ-3 dietary supplementation, which may be important in inflammation, neoplasia, and vascular diseases.
Resolvin D1 binds human phagocytes with evidence for proresolving receptors
TLDR
It is demonstrated that RvD1 actions on human polymorphonuclear leukocytes (PMNs) are pertussis toxin sensitive, decrease actin polymerization, and block LTB4-regulated adhesion molecules (β2 integrins).
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
TLDR
Novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation are demonstrated.
Resolvin E1 and protectin D1 activate inflammation-resolution programmes
TLDR
It is demonstrated that RvE1 and PD1 are potent agonists for resolution of inflamed tissues by identifying new active components for postexudate resolution traffic, and identifying new resolution routes that involve phagocytes traversing perinodal adipose tissues and non-apoptotic polymorphonuclear neutrophils carrying engulfed zymosan to lymph nodes.
...
1
2
3
4
5
...