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Synucleins

Known as: Synuclein, Synucleins [Chemical/Ingredient] 
A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been implicated in a variety of… 
National Institutes of Health

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alpha-Synuclein

Papers overview

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Highly Cited
2010
Highly Cited
2010
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
Protein misfolding and formation of β-sheet-rich amyloid fibrils or aggregates is related to cellular toxicity and decay in… 
Highly Cited
2005
Highly Cited
2005
Structure and Dynamics of Micelle-bound Human α-Synuclein*
Misfolding of the protein α-synuclein (aS), which associates with presynaptic vesicles, has been implicated in the molecular… 
Highly Cited
2003
Highly Cited
2003
Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation
Previous studies demonstrated that chronic systemic exposure to the pesticide and mitochondrial toxin rotenone through jugular… 
Highly Cited
2002
Highly Cited
2002
Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice
Mutations in α-synuclein (α-Syn) cause Parkinson's disease (PD) in a small number of pedigrees with familial PD. Moreover, α-Syn… 
Review
2001
Review
2001
The synucleins
SummarySynucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes… 
Highly Cited
2000
Highly Cited
2000
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
Two missense mutations in the gene encoding alpha-synuclein have been linked to rare, early-onset forms of Parkinson's disease… 
Highly Cited
1999
Highly Cited
1999
Both Familial Parkinson’s Disease Mutations Accelerate α-Synuclein Aggregation*
Parkinson’s disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic… 
Highly Cited
1998
Highly Cited
1998
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
Lewy bodies (LBs) are hallmark lesions of degenerating neurons in the brains of patients with Parkinson's disease (PD) and… 
Highly Cited
1994
Highly Cited
1994
Identification of two distinct synucleins from human brain
Highly Cited
1988
Highly Cited
1988
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
We used an antiserum against purified cholinergic synaptic vesicles from Torpedo and expression screening to isolate a cDNA clone… 
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