γ-Synuclein as a marker of retinal ganglion cells

@article{Surgucheva2008SynucleinAA,
  title={γ-Synuclein as a marker of retinal ganglion cells},
  author={Irina Surgucheva and Alejandra D. Weisman and Jeffrey L. Goldberg and Alexander A. Shnyra and Andrei Surguchov},
  journal={Molecular Vision},
  year={2008},
  volume={14},
  pages={1540 - 1548}
}
PURPOSE Previous studies have described gamma-synuclein as a protein highly expressed in retinal ganglion cells (RGCs), and a loss of RGCs correlates with a downregulation of gamma-synuclein gene expression in glaucoma. Here we asked whether gamma-synuclein expression in the retina can be considered a specific marker of RGCs. METHODS gamma-Synuclein expression was examined with immunohistochemistry in retinal sections from normal and glaucomatous human eyes. Primary cultures of RGCs from… CONTINUE READING

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