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Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.
TLDR
Results may imply that DJ-1 plays an important role in the neuronal defense mechanism against oxidative insults, after exposure of naïve neuroblastoma cells to rotenone or 6-hydroxydopamine induced upregulation ofDJ-1 mRNA and protein levels. Expand
Progressive multifocal leukoencephalopathy in transplant recipients
TLDR
Progressive multifocal leukoencephalopathy is a unique entity that should be considered in any transplant recipient with neurological symptoms and is usually fatal, although regression has been reported. Expand
Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis‐like disease in C57BL/6 mice
TLDR
Phytocannabinoids like cannabidiol (CBD), devoid of psychoactive activity, are, potentially, safe and effective alternatives for alleviating neuroinflammation and neurodegeneration. Expand
Apoptosis and Parkinson's disease
TLDR
Evidence for the role of apoptotic cell death in PD arises from morphological, as well as molecular, studies in cell cultures, animal models for PD, aswell as human studies on postmortem brains from PD patients, which indicate that apoptosis takes place and that there is a proapoptotic environment in the nigrostriatal region of parkinsonian patients. Expand
Transplantation of Placenta-Derived Mesenchymal Stem Cells in the EAE Mouse Model of MS
TLDR
It is demonstrated that PL-MSCs have a therapeutic effect in the EAE mice model, and it is assumed that this effect is caused by reduction of the anti-inflammatory protein, TSG-6, of the inflammatory damage. Expand
Features associated with epilepsy in the antiphospholipid syndrome.
TLDR
Epilepsy is common in APS and most of the risk seems to be linked to vascular disease as manifested by extensive CNS involvement, valvulopathy, and livedo reticularis and to the presence of SLE. Expand
Intracerebral adult stem cells transplantation increases brain-derived neurotrophic factor levels and protects against phencyclidine-induced social deficit in mice
TLDR
The results demonstrate that intracerebral transplantation of MSCs is beneficial in attenuating the social deficits induced by sub-chronic PCP administration and suggest a novel therapeutic approach for the treatment of schizophrenia-like negative symptoms in animal models of the disorder. Expand
DJ-1 protects against dopamine toxicity
TLDR
It is shown that DJ-1 protects against dopamine toxicity and elucidates how mutations inDJ-1 prompt PD and implies that modulation of DJ- 1 may serve as a novel neuroprotective modality. Expand
Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosis.
TLDR
It is believed that DJ-1 will be found to have a central role in MS because of the accumulating evidence on the central role of oxidative stress in MS, and the importance ofDJ-1 in oxidative stress management by the CNS. Expand
Tumefactive demyelination and a malignant course in an MS patient during and following fingolimod therapy
TLDR
An MS patient who developed a giant cavitating brain lesion under fingolimod is presented and brain biopsy revealed the lesion to be due to an active demyelinating inflammatory process. Expand
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