• Publications
  • Influence
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
TLDR
Findings show berberine (BBR) as a new hypolipidemic drug with a mechanism of action different from that of statin drugs.
Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.
TLDR
Data demonstrate that As(2)O(3) has a paclitaxel-like effect, markedly promotes tubulin polymerization, arrests cell cycle at mitosis, and induces apoptosis, as well as being a poor substrate for transport by P-glycoprotein and MRP, and non-cross-resistant with pac litaxel resistant cell lines due to tubulin mutation.
Combination of simvastatin with berberine improves the lipid-lowering efficacy.
Loss of epigenetic control of synuclein-gamma gene as a molecular indicator of metastasis in a wide range of human cancers.
TLDR
It is shown that the neuronal protein synuclein-gamma (SNCG) is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, but rarely expressed in tumor-matched nonneoplastic adjacent tissues, suggesting that its expression in primary carcinomas is an effective molecular indicator of distant metastasis.
PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorylation and cleavage in association with G2-M phase arrest and apoptosis.
TLDR
The inhibition of the ubiquitin/proteasome pathway by PS-341 leads, at an early stage of apoptosis, to Bcl-2 phosphorylation and a unique proteolytic cleavage product, which are associated with G2-M phase arrest and the induction of apoptoses.
Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines.
TLDR
The data suggest that the PS-341-induced G(2)-M-phase arrest may be associated with the inhibition of degradation of cell cycle regulators and that the up-regulation of p21(cip/waf-1) expression may be via p53-dependent and/or -independent pathways.
Geldanamycin, a Ligand of Heat Shock Protein 90, Inhibits the Replication of Herpes Simplex Virus Type 1 In Vitro
TLDR
The antiviral mechanism of GA appears to be associated with Hsp90 inactivation and cell cycle restoration, which indicates that GA exhibits broad-spectrum antiviral activity.
Transforming berberine into its intestine-absorbable form by the gut microbiota
TLDR
It is shown that the gut microbiota converts BBR into its absorbable form of dihydroberberine (dhBBR), which has an intestinal absorption rate 5-fold that of BBR in animals.
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease
TLDR
Animal experiments showed that BBR located favorably in the liver and altered hepatic metabolism-related gene expression in an animal model of NAFLD treated with BBR, suggesting that the therapeutic effect of BBR may involve a direct regulation of hepatic lipid metabolism.
...
1
2
3
4
5
...