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Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
Findings show berberine (BBR) as a new hypolipidemic drug with a mechanism of action different from that of statin drugs.
Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.
Data demonstrate that As(2)O(3) has a paclitaxel-like effect, markedly promotes tubulin polymerization, arrests cell cycle at mitosis, and induces apoptosis, as well as being a poor substrate for transport by P-glycoprotein and MRP, and non-cross-resistant with pac litaxel resistant cell lines due to tubulin mutation.
Combination of simvastatin with berberine improves the lipid-lowering efficacy.
Loss of epigenetic control of synuclein-gamma gene as a molecular indicator of metastasis in a wide range of human cancers.
It is shown that the neuronal protein synuclein-gamma (SNCG) is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, but rarely expressed in tumor-matched nonneoplastic adjacent tissues, suggesting that its expression in primary carcinomas is an effective molecular indicator of distant metastasis.
PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorylation and cleavage in association with G2-M phase arrest and apoptosis.
The inhibition of the ubiquitin/proteasome pathway by PS-341 leads, at an early stage of apoptosis, to Bcl-2 phosphorylation and a unique proteolytic cleavage product, which are associated with G2-M phase arrest and the induction of apoptoses.
Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines.
The data suggest that the PS-341-induced G(2)-M-phase arrest may be associated with the inhibition of degradation of cell cycle regulators and that the up-regulation of p21(cip/waf-1) expression may be via p53-dependent and/or -independent pathways.
Geldanamycin, a Ligand of Heat Shock Protein 90, Inhibits the Replication of Herpes Simplex Virus Type 1 In Vitro
The antiviral mechanism of GA appears to be associated with Hsp90 inactivation and cell cycle restoration, which indicates that GA exhibits broad-spectrum antiviral activity.
Transforming berberine into its intestine-absorbable form by the gut microbiota
It is shown that the gut microbiota converts BBR into its absorbable form of dihydroberberine (dhBBR), which has an intestinal absorption rate 5-fold that of BBR in animals.
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease
Animal experiments showed that BBR located favorably in the liver and altered hepatic metabolism-related gene expression in an animal model of NAFLD treated with BBR, suggesting that the therapeutic effect of BBR may involve a direct regulation of hepatic lipid metabolism.