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abatacept

Known as: CTLA4IgG4m, CTLA4-Ig, CTLA4-IgG4m 
A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc… 
National Institutes of Health

Related topics

Related topics

16 relations
1 ML abatacept 125 MG/ML Auto-Injector1 ML abatacept 125 MG/ML Prefilled Syringe [Orencia]CTLA4 protein, humanIn Blood

Broader (2)

Antirheumatic AgentsImmunosuppressive Agents

Narrower (6)

BMS 188667BMS224818CTLA-4-IgLEA29Y

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
The risk of infections with biologic therapies for rheumatoid arthritis.
Highly Cited
2000
Highly Cited
2000
Characterization of Human Inducible Costimulator Ligand Expression and Function1
The inducible costimulator (ICOS) is the newest member of the CD28/CD152 receptor family involved in regulating T cell activation… 
Highly Cited
1998
Highly Cited
1998
Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance
A reliable, nontoxic method of inducing transplantation tolerance is needed to overcome the problems of chronic organ graft… 
Highly Cited
1996
Highly Cited
1996
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.
Recent data implicates a role for the CD40-CD40 ligand (CD40L) pathway in graft rejection. One potential mechanism is direct… 
Highly Cited
1995
Highly Cited
1995
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
Insulin-dependent diabetes mellitus (IDDM) is thought to be an immunologically mediated disease resulting in the complete… 
Highly Cited
1995
Highly Cited
1995
CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
Blocking the CD28-B7 T cell costimulatory pathway with the fusion protein CTLA4Ig inhibits alloimmune responses in vitro and in… 
Highly Cited
1994
Highly Cited
1994
B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells
Dendritic cells comprise a system of highly efficient antigen- presenting cells involved in the initiation of T cell responses… 
Highly Cited
1994
Highly Cited
1994
Transplantation tolerance induced by CTLA4-Ig.
The rejection of the transplanted allograft is dependent on T cell activation, which requires T cell receptor engagement by… 
Highly Cited
1994
Highly Cited
1994
CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production
Naive T cells require interleukin 4 (IL-4) to develop into IL-4- producing T cells and IL-4 blocks development of such cells into… 
Highly Cited
1993
Highly Cited
1993
Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1
The specificity of T lymphocyte activation is determined by engagement of the T cell receptor (TCR) by peptide/major… 
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