abatacept

Known as: CTLA4IgG4m, CTLA4-Ig, CTLA4-IgG4m 
A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Recent insights in rheumatoid arthritis (RA) necessitated updating the European League Against Rheumatism (EULAR) RA management… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND The immunopathogenesis of type 1 diabetes mellitus is associated with T-cell autoimmunity. To be fully active, immune… (More)
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Highly Cited
2011
Highly Cited
2011
OBJECTIVE To compare the efficacy and safety of subcutaneous (SC) and intravenous (IV) abatacept. METHODS In this phase IIIb… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Several agents provide treatment for established rheumatoid arthritis (RA), but a crucial therapeutic goal is to delay… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVES To assess the efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis (RA) and… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Some children with juvenile idiopathic arthritis either do not respond, or are intolerant to, treatment with disease… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES This double-blind trial evaluated the efficacy and safety of abatacept or infliximab vs placebo. The primary objective… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND A substantial number of patients with rheumatoid arthritis have an inadequate or unsustained response to tumor… (More)
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Highly Cited
2005
Highly Cited
2005
OBJECTIVE To determine the clinical efficacy, safety, and immunogenicity of abatacept (CTLA-4Ig), a selective costimulation… (More)
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Highly Cited
1996
Highly Cited
1996
Antigen presentation by host dendritic cells (DC) is critical for the initiation of adaptive immune responses. We have previously… (More)
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