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Trafficking from bedside to bench Typically in translational research, a discovery in cell or molecular biology is later… Expand HS Kuehn, W Ouyang, B Lo. Science. 2014;345(6204):1623–1627
Identify the possible genetic basis among a group of patients… Expand The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes… Expand Beware of T cells that don't know how to stop During an infection, T cells divide extensively and secrete proteins that can… Expand Combination therapies for melanoma that target immune-regulatory networks are entering clinical practice, and more are under… Expand Cytotoxic T lymphocyte antigen-4 has become recognized as one of the key negative regulators of adaptive immune responses, having… Expand Candidate-gene association studies in rheumatoid arthritis (RA) have lead to encouraging yet apparently inconsistent results. One… Expand Blocking the interaction of the CD28 costimulatory receptor with its ligands, CD80 and CD86, inhibits in vivo immune responses… Expand CTLA4 is a cell surface molecule that shares 30% homology with CD28 and binds B7 family members with high affinity. Analysis of… Expand We present a PCR-based Mse I restriction fragment length polymorphism (RFLP) in the promotor of the human CTLA4 gene at position… Expand