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CTLA4 protein, human

Known as: cytotoxic T-lymphocyte-associated protein 4, human, Cytotoxic T-Lymphocyte-Associated Antigen 4, Cytotoxic T-Lymphocyte Protein 4 
Cytotoxic T-lymphocyte protein 4 (223 aa, ~25 kDa) is encoded by the human CTLA4 gene. This protein is involved in the inhibition of T-cell mediated… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Mutations in the LRBA gene (encoding the lipopolysaccharide-responsive and beige-like anchor protein) cause a syndrome of… Expand
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Highly Cited
2015
Highly Cited
2015
HS Kuehn, W Ouyang, B Lo. Science. 2014;345(6204):1623–1627 Identify the possible genetic basis among a group of patients… Expand
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Highly Cited
2014
Highly Cited
2014
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes… Expand
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Highly Cited
2014
Highly Cited
2014
Cytotoxic T lymphocyte antigen–4 (CTLA-4) is an inhibitory receptor found on immune cells. The consequences of mutations in CTLA4… Expand
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Highly Cited
2014
Highly Cited
2014
Combination therapies for melanoma that target immune-regulatory networks are entering clinical practice, and more are under… Expand
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Review
2006
Review
2006
Cytotoxic T lymphocyte antigen-4 has become recognized as one of the key negative regulators of adaptive immune responses, having… Expand
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Highly Cited
2005
Highly Cited
2005
Coeliac disease is a common enteropathy with a strong inherited risk characterised by dietary wheat, rye and barley induced T… Expand
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Highly Cited
2001
Highly Cited
2001
To examine whether B7 costimulation can be mediated by a molecule on T cells that is neither CD28 nor CTLA4, we generated mice… Expand
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Highly Cited
1999
Highly Cited
1999
Blocking the interaction of the CD28 costimulatory receptor with its ligands, CD80 and CD86, inhibits in vivo immune responses… Expand
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Highly Cited
1996
Highly Cited
1996
CTLA4 is a cell surface molecule that shares 30% homology with CD28 and binds B7 family members with high affinity. Analysis of… Expand
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