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CTLA4 protein, human

Known as: cytotoxic T-lymphocyte-associated protein 4, human, Cytotoxic T-Lymphocyte-Associated Antigen 4, Cytotoxic T-Lymphocyte Protein 4 
Cytotoxic T-lymphocyte protein 4 (223 aa, ~25 kDa) is encoded by the human CTLA4 gene. This protein is involved in the inhibition of T-cell mediated… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Trafficking from bedside to bench Typically in translational research, a discovery in cell or molecular biology is later… Expand
Highly Cited
2015
Highly Cited
2015
HS Kuehn, W Ouyang, B Lo. Science. 2014;345(6204):1623–1627 Identify the possible genetic basis among a group of patients… Expand
Highly Cited
2014
Highly Cited
2014
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes… Expand
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Highly Cited
2014
Highly Cited
2014
Beware of T cells that don't know how to stop During an infection, T cells divide extensively and secrete proteins that can… Expand
Highly Cited
2014
Highly Cited
2014
Combination therapies for melanoma that target immune-regulatory networks are entering clinical practice, and more are under… Expand
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Review
2006
Review
2006
Cytotoxic T lymphocyte antigen-4 has become recognized as one of the key negative regulators of adaptive immune responses, having… Expand
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Review
2005
Review
2005
Candidate-gene association studies in rheumatoid arthritis (RA) have lead to encouraging yet apparently inconsistent results. One… Expand
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Highly Cited
1999
Highly Cited
1999
Blocking the interaction of the CD28 costimulatory receptor with its ligands, CD80 and CD86, inhibits in vivo immune responses… Expand
Highly Cited
1996
Highly Cited
1996
CTLA4 is a cell surface molecule that shares 30% homology with CD28 and binds B7 family members with high affinity. Analysis of… Expand
Highly Cited
1996
Highly Cited
1996
We present a PCR-based Mse I restriction fragment length polymorphism (RFLP) in the promotor of the human CTLA4 gene at position… Expand