CTLA4 protein, human

Known as: cytotoxic T-lymphocyte-associated protein 4, human, Cytotoxic T-Lymphocyte-Associated Antigen 4, Cytotoxic T-Lymphocyte Protein 4 
Cytotoxic T-lymphocyte protein 4 (223 aa, ~25 kDa) is encoded by the human CTLA4 gene. This protein is involved in the inhibition of T-cell mediated… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
02040608019912017

Papers overview

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Review
2016
Review
2016
Patients with advanced melanoma have traditionally had very poor prognosis. However, since 2011 better understanding of the… (More)
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Highly Cited
2015
Highly Cited
2015
Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4… (More)
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Highly Cited
2014
Highly Cited
2014
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an inhibitory receptor found on immune cells. The consequences of mutations in CTLA4… (More)
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Highly Cited
2013
Highly Cited
2013
Treatment with monoclonal antibody specific for cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), an inhibitory receptor… (More)
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Highly Cited
2007
Highly Cited
2007
A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3… (More)
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Highly Cited
2006
Highly Cited
2006
CTL-associated antigen 4 (CTLA4) blockade releases inhibitory controls on T cell activation and proliferation, inducing antitumor… (More)
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Highly Cited
2005
Highly Cited
2005
CTLA-4 and PD-1 are receptors that negatively regulate T-cell activation. Ligation of both CTLA-4 and PD-1 blocked CD3/CD28… (More)
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Highly Cited
2004
Highly Cited
2004
Murine dendritic cells (DCs) expressing indoleamine 2,3 dioxygenase (IDO) catabolize tryptophan and can suppress T cell responses… (More)
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Highly Cited
2003
Highly Cited
2003
Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the… (More)
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Highly Cited
1997
Highly Cited
1997
The identification of potentially useful immune-based treatments for prostate cancer has been severely constrained by the… (More)
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