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Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
TLDR
It is shown that cardiac fibrosis is associated with the emergence of fibroblasts originating from endothelial cells, suggesting an endothelial-mesenchymal transition (EndMT) similar to events that occur during formation of the atrioventricular cushion in the embryonic heart. Expand
Delayed graft function in kidney transplantation
TLDR
It is learnt that both ischaemia and reinstitution of blood flow in ischaemically damaged kidneys after hypothermic preservation activate a complex sequence of events that sustain renal injury and play a pivotal part in the development of delayed graft function. Expand
Identification of cells initiating human melanomas
TLDR
This work identifies a subpopulation enriched for human malignant-melanoma-initiating cells (MMIC) defined by expression of the chemoresistance mediator ABCB5 and shows that specific targeting of this tumorigenic minority population inhibits tumour growth. Expand
Tissue expression of PD-L1 mediates peripheral T cell tolerance
TLDR
Evidence is provided that PD-L 1 expression on parenchymal cells rather than hematopoietic cells protects against autoimmune diabetes and point to a novel role for PD-1–PD-L1 interactions in mediating tissue tolerance. Expand
Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis
TLDR
The programmed death-1 (PD-1) costimulatory pathway plays a critical role in regulating peripheral tolerance in murine EAE and appears to be a major contributor to the resistance of disease induction in CD28-deficient mice. Expand
Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.
TLDR
The findings suggest that TIM-1 may be a novel therapeutic target for modulating the immune response and provide insight into the signals involved in the generation and induction of Bregs. Expand
The role of T-cell costimulatory activation pathways in transplant rejection.
TLDR
The development of new immunosuppressive drugs with improved efficacy and decreased toxicity has led to substantial improvement in the survival of patients and in short-term graft survival over the past two decades. Expand
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
TLDR
It is shown that ABCB5, which functions as a determinant of membrane potential and regulator of cell fusion in physiologic skin progenitor cells, is expressed in clinical malignant melanoma tumors and preferentially marks a subset of hyperpolarized, CD133+ stem cell phenotype-expressing tumor cells in malignant sunscreen cultures and clinical melanomas. Expand
Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.
TLDR
It is found that mice deficient in STAT4 are resistant to the induction of EAE, with minimal inflammatory infiltrates in the central nervous system, and adoptive transfer studies confirm the regulatory functions of a Th2 environment in vivo. Expand
Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens.
TLDR
Orally administered autoantigens suppress several experimental autoimmune models in a disease- and antigen-specific fashion; the diseases include experimental autoimmune encephalomyelitis, uveitis, and myasthenia, collagen- and adjuvant-induced arthritis, and diabetes in the NOD mouse. Expand
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