Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance

@article{Wekerle1998ExtrathymicTC,
  title={Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance },
  author={Thomas Wekerle and Mohamed H. Sayegh and Joshua A Hill and Yong Zhao and Anil K. Chandraker and Kirsten G. Swenson and Guiling Zhao and Megan Sykes},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={187},
  pages={2037 - 2044}
}
A reliable, nontoxic method of inducing transplantation tolerance is needed to overcome the problems of chronic organ graft rejection and immunosuppression-related toxicity. Treatment of mice with single injections of an anti-CD40 ligand antibody and CTLA4Ig, a low dose (3 Gy) of whole body irradiation, plus fully major histocompatibility complex-mismatched allogeneic bone marrow transplantation (BMT) reliably induced high levels (>40%) of stable (>8 mo) multilineage donor hematopoiesis… CONTINUE READING

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Costimulatory function of CD40L, CD80 and CD86 in vascularized murine cardiac allograft rejection

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